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DRUG DELIVERY COMPOSITION AND PHARMACEUTICAL COMPOSITION NEW

外国特許コード F210010302
整理番号 (S2019-0497-N0)
掲載日 2021年1月29日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2020JP018512
国際公開番号 WO 2020255574
国際出願日 令和2年5月7日(2020.5.7)
国際公開日 令和2年12月24日(2020.12.24)
優先権データ
  • 特願2019-115688 (2019.6.21) JP
発明の名称 (英語) DRUG DELIVERY COMPOSITION AND PHARMACEUTICAL COMPOSITION NEW
発明の概要(英語) This drug delivery composition is for the delivery of a drug to the spinal cord; comprises a membrane-permeable peptide and a block copolymer in which a polyethylene glycol segment is linked to a hydrophobic polyester segment; and is administered nasally. This pharmaceutical composition comprises the drug delivery composition and a drug for the treatment of a spinal cord disease and is administered nasally for the treatment of a spinal cord disease.
従来技術、競合技術の概要(英語) BACKGROUND ART
Drug delivery to the spinal cord via systemic circulating blood by oral or intravenous administration is significantly limited by the blood-brain barrier and blood-cerebrospinal fluid barrier, making it difficult to increase the drug concentration in spinal cord tissue to the therapeutic area. In addition, because a large amount of medicament is administered to increase the treatment area, side effects on peripheral tissues may be exhibited via systemic circulation. Intrathecal administration can selectively deliver drugs to spinal cord tissue, but administration planning is difficult because administration requires techniques, is highly invasive, and bears a large burden on a patient.
On the other hand, drug delivery technology has been developed as a technology for delivering drugs to disease sites. g. Methoxypolyethylene glycol (Methoxy Polyethylene Glycol: MPEG) segments and poly (epsilon-caprolactone) (Poly (epsilon-caprolactone): (Patent Document 1) reports a nucleic acid delivery composition containing a block copolymer consisting of PCL) segments and a peptide comprising a liposoluble group consisting of 10 amino acids including arginine and histidine.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NIHON UNIVERSITY
  • SHIZUOKA PREFECTURAL UNIVERSITY CORPORATION
  • 発明者(英語)
  • KANAZAWA Takanori
  • KOSUGE Yasuhiro
  • MIYAGISHI Hiroko
  • SUZUKI Naoto
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN WS ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL ST SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
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