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HYDROPHILIC-HYDROPHOBIC COPOLYMER CARRYING SHORT-CHAIN FATTY ACID ESTER

外国特許コード F210010366
整理番号 (S2019-0604-N0)
掲載日 2021年4月27日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2020JP029239
国際公開番号 WO 2021024906
国際出願日 令和2年7月30日(2020.7.30)
国際公開日 令和3年2月11日(2021.2.11)
優先権データ
  • 特願2019-143619 (2019.8.5) JP
発明の名称 (英語) HYDROPHILIC-HYDROPHOBIC COPOLYMER CARRYING SHORT-CHAIN FATTY ACID ESTER
発明の概要(英語) [Problem] To provide a short-chain fatty acid derivative capable of performing a physiological function inherent to a short chain fatty acid.
[Solution] Provided is a block or graft copolymer containing: a hydrophobic segment having a repeating unit including a short-chain fatty acid that can be hydrolyzed by an esterase in vivo; and a hydrophilic segment including a poly(ethylene glycol) chain. This copolymer is effective in treating or therapeutically treating various diseases or disorders including cancer.
従来技術、競合技術の概要(英語) BACKGROUND ART
Short-chain fatty acids such as acetic acid, propionic acid, butyric acid (or butanoic acid) have been reported to have various physiological functions such as immunosuppressive ability, liver fibrosis suppressive ability, obesity suppressive ability, and anticancer ability depending on the chain length thereof (see, for example, Non-Patent Document 1). The short-chain fatty acids having physiological functions described above are produced from sugars by the gut microflora, but are not necessarily sufficient, and sufficient supply is expected.
However, short-chain fatty acids are not only limited in their method of administration due to their solubility and odor, but also their metabolism is fast due to their low molecular weight, and their physiological function changes due to their association, which is difficult to handle. Therefore, although provided as a part of supplements or the like, it is not stated that there is no effective administration method or formulation capable of exhibiting physiological functions essentially of short-chain fatty acids.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • UNIVERSITY OF TSUKUBA
  • 発明者(英語)
  • NAGASAKI, Yukio
  • SHASHNI, Babita
  • VONG, Binh Long
  • OKADA, Ryusaku
  • TAJIKA, Yuya
  • LEE, Yaroslav
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS IT JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN WS ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
この特許について質問等ある場合は、電子メールによりご連絡ください。

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