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MICRODROPLET/BUBBLE GENERATION DEVICE NEW

外国特許コード F210010586
整理番号 (S2020-0225-N0)
掲載日 2021年11月2日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2021JP010205
国際公開番号 WO 2021182632
国際出願日 令和3年3月12日(2021.3.12)
国際公開日 令和3年9月16日(2021.9.16)
優先権データ
  • 特願2020-044633 (2020.3.13) JP
発明の名称 (英語) MICRODROPLET/BUBBLE GENERATION DEVICE NEW
発明の概要(英語) A microdroplet/bubble generation device comprising a slit and a row of a plurality of microchannels, wherein: a continuous phase or a dispersed phase is fed to the slit; an end of the slit, a feed port for the other of the continuous phase or dispersed phase, and a discharge port are connected to the plurality of microchannels; the plurality of microchannels have, adjacent to or in the vicinity of the site of connection with the slit, a constricted part at which the cross-sectional area of the channel is locally reduced; the continuous phase and the dispersed phase meeting at the site of connection flow into the constricted part; the dispersed phase is sheared in the constricted part with the flow of the continuous phase acting as a driving force; bubbles or droplets of the dispersed phase are generated; and the generated product is recovered from the discharge port.
従来技術、競合技術の概要(英語) BACKGROUND ART
Micro droplet and bubble generation methods using a branched structure of micro channels can generate emulsion droplets and bubbles having excellent monodispersity, and are therefore applied in various fields including chemical and biochemical analysis. However, when this method is applied to production technology, it is difficult to achieve a required production volume, for example, several tons/year, with a single microchannel (NpL 1 and NpL 2).
In order to greatly increase (scale-up) the amount of droplets and bubbles generated under such circumstances, attempts have been reported to arrange a large number of microflow channels in parallel (NpL 3 and NpL 4). In the generation of micro droplets and bubbles using a branched structure of the micro flow path, the sizes of the generated droplets and bubbles change depending on the flow rates of the dispersed phase and the continuous phase. thus, in order to generate droplets and bubbles of uniform size, it is necessary to distribute and supply the dispersed phase and the continuous phase uniformly to the micro flow paths arranged in parallel. In the conventional parallelization device, uniform flow rate distribution to each of the generation channels is achieved by a structure in which a symmetrically branched distribution channel is connected to each of the generation channels (NpL 3~ 5), or by a structure in which a channel sufficiently large in size to the size of the generation channel is connected in a ladder-like manner (NpL 5~ 7). In the past, a case has been reported in which a maximum of 512 cross-shaped droplet generating channels are arranged in parallel in an annular shape using a dispensing channel with a symmetrical branch structure (Non-Patent Document 8), and a case in which a maximum of 1000 droplet generating channels are arranged in parallel in a matrix using a ladder-shaped liquid dispensing channel (Non-Patent Document 9). A case of mass production of gas bubbles using the same apparatus has also been reported (NpL 10). Further, a device in which a liquid supply channel and a droplet generating channel are detachable has also been proposed (NpL 2 and NpL 3).
On the other hand, in a conventional parallelized device, individual through-holes corresponding to the channels for generating droplets or bubbles are formed in order to connect the channels for distributing the liquid or gas and the channels for generating droplets or bubbles. thus, complicated device manufacturing processes are required.
Patent Document 1 proposes a micro droplet and bubble generating device that does not require individual through-holes corresponding to each droplet or bubble generating flow path due to a simple configuration in which a slit and a micro flow path array are three-dimensionally combined, rather than arranging droplet or bubble generating flow paths on a two-dimensional plane. This device is a micro droplet and bubble generating device that can be easily mounted and managed and in which micro droplets or bubble generating parts are densely arranged. However, with this device, when small sized droplets or bubbles are generated, a small sized flow path is simply used, and there is a problem in that there is a high pressure loss and a higher risk of clogging.
On the other hand, as the conventional micro flow path technique related to the present invention, a technique in which a continuous phase supply flow path is disposed on both sides of a dispersion phase supply flow path on a substrate, the flow of the dispersion phase is sandwiched between the flow of the continuous phase and supplied to a location where the flow path is locally narrowed, and droplets or bubbles are generated (flow focusing) have been widely used (NpL 11). However, in the present technology, because two continuous phase supply flow paths are arranged on both sides of one dispersion phase supply flow path, there is a problem that the present technology is not suitable for high-density integration.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOKYO INSTITUTE OF TECHNOLOGY
  • 発明者(英語)
  • NISISAKO, Takasi
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS IT JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN WS ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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