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COLUMN FILLER FOR LIQUID CHROMATOGRAPHY, AND METHOD FOR PRODUCING SAME UPDATE

外国特許コード F210010607
整理番号 (S2020-0292-N0)
掲載日 2021年12月20日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2021JP018442
国際公開番号 WO 2021230355
国際出願日 令和3年5月14日(2021.5.14)
国際公開日 令和3年11月18日(2021.11.18)
優先権データ
  • 特願2020-084901 (2020.5.14) JP
発明の名称 (英語) COLUMN FILLER FOR LIQUID CHROMATOGRAPHY, AND METHOD FOR PRODUCING SAME UPDATE
発明の概要(英語) Disclosed are: a novel column filler which is for a liquid chromatography, is alkali resistant, has the separability and pressure resistance required as a column filler for a liquid chromatography, and can be mass-produced on a commercial basis; and a method for producing same. The column filler for a liquid chromatography is composed of eggshells or seashells that have been crushed, and subjected to a treatment using a calcium removing agent and to a biopolymer removal treatment. The method for producing a column filler for a liquid chromatography includes subjecting crushed eggshells or seashells to a treatment using a calcium removing agent and to a biopolymer removal treatment.
従来技術、競合技術の概要(英語) BACKGROUND ART
Conventionally, chemically modified silica gels such as octadecyl silica (ODS silica) and the like have been widely used as column fillers for liquid chromatography. However, silica gel based fillers have the disadvantage that silica gel dissolution and chemical modification detachment occur in an alkaline aqueous solution, and a mobile phase of high pH cannot be used. On the other hand, it is desirable to use an alkaline mobile phase in order to obtain favorable separation of various chemicals and the like in alkalinity. therefore, there is a demand for an alkali-resistant filler.
The present inventors previously developed a porous spherical calcium carbonate-based high-performance liquid chromatography (HPLC) filler as an alkali-resistant filler (Non-Patent Document 1). This filler is a high alkali resistant reverse phase HPLC filler in which the surface of artificially synthesized vaterite-type porous calcium carbonate crystal particles is coated with a hydrophobic group-containing polymer to impart a hydrophobic interaction function.
In addition, it is also known that pulverized shells are used as column fillers for liquid chromatography (NpL 2). However, the separation performance thereof cannot necessarily be satisfied.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KEIO UNIVERSITY
  • 発明者(英語)
  • HIRUTA,Yuki
  • MOCHIDA, Mai
  • IMAI, Hiroaki
  • YOSHII, Tomoka
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS IT JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN WS ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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