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METHOD FOR PREPARATION OF HEPATOCYTE USING ES CELL

Foreign code F070001817
File No. F070001817
Posted date Mar 28, 2008
Country WIPO
International application number 2006JP306783
International publication number WO 2007/110966
Date of international filing Mar 24, 2006
Date of international publication Oct 4, 2007
Title METHOD FOR PREPARATION OF HEPATOCYTE USING ES CELL
Abstract Disclosed is a promoter for the differentiation of an ES cell, preferably a promoter for the differentiation of an ES cell into a hepatocyte, containing uPA or a prophylactic agent for teratoma. Also disclosed is a method for promoting the differentiation of an ES cell, preferably the differentiation of an ES cell into a hepatocyte, comprising the step of contacting uPA with the ES cell, or a method for preparing a hepatocyte comprising the step of contacting uPA with an ES cell to cause the differentiation of the ES cell into a hepatocyte.
Scope of claims (In Japanese)
【請求項1】ウロキナーゼ型プラスミノゲン活性化因子を含有する、ES細胞の分化促進剤。

【請求項2】ウロキナーゼ型プラスミノゲン活性化因子を含有する、ES細胞から肝細胞への分化促進剤。

【請求項3】ウロキナーゼ型プラスミノゲン活性化因子を含有する、テラトーマ予防剤。

【請求項4】ウロキナーゼ型プラスミノゲン活性化因子をES細胞に接触させることを含む、ES細胞の分化促進方法。

【請求項5】ウロキナーゼ型プラスミノゲン活性化因子をES細胞に接触させることを含む、ES細胞から肝細胞への分化促進方法。

【請求項6】ウロキナーゼ型プラスミノゲン活性化因子をES細胞に接触させ、当該ES細胞を肝細胞に分化させることを含む、肝細胞の調製方法。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • Nihon University
  • Inventor
  • Ariga, Toyohiko
  • Seki, Taiichiro
  • Watanabe, Go
  • Nakashima, Hiroto
  • Okumura, Nobuaki
  • Hasebe, Yuichi
IPC(International Patent Classification)
Specified countries AE AG AL AM AT AU AZ BA BB BE BF BG BJ BR BW BY BZ CA CF CG CH CI CM CN CO CR CU CY CZ DE DK DM DZ EC EE EG ES FI FR GA GB GD GE GH GM GN GQ GR GW HR HU ID IE IL IN IS IT JP KE KG KM KN KP KR KZ LC LK LR LS LT LU LV LY MA MC MD MG MK ML MN MR MW MX MZ NA NE NG NI NL NO NZ OM PG PH PL PT RO RU SC SD SE SG SI SK SL SM SN SY SZ TD TG TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW
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