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Cytidine deaminase UPDATE

外国特許コード F080001883
整理番号 F080001883
掲載日 2008年6月27日
出願国 アメリカ合衆国
出願番号 88487804
公報番号 20050054073
公報番号 7083966
出願日 平成16年7月2日(2004.7.2)
公報発行日 平成17年3月10日(2005.3.10)
公報発行日 平成18年8月1日(2006.8.1)
国際出願番号 JP2000001918
国際公開番号 WO2000058480
国際出願日 平成12年3月28日(2000.3.28)
国際公開日 平成12年10月5日(2000.10.5)
優先権データ
  • 特願1999-087192 (1999.3.29) JP
  • 特願1999-178999 (1999.6.24) JP
  • 特願1999-371382 (1999.12.27) JP
  • 2000WO-JP01918 (2000.3.28) WO
  • 2001US-09966880 (2001.9.28) US
発明の名称 (英語) Cytidine deaminase UPDATE
発明の概要(英語) (US7083966)
Genes encoding novel proteins named AID (Activation-Induced cytidine Deaminase) are described.
The AID proteins are structurally related to APOBEC-1, an RNA editing enzyme, and have a cytidine deaminase activity similar to APOBEC-1.
The AID genes were found by preparing cDNA libraries from mouse B cell clone CH12F3-2 (which undergoes class switch recombination from IgM to IgA at an extremely high rate after activation of the cells by stimulation with cytokines), with and without stimulation with cytokines, and performing subtraction cloning using the libranes.
特許請求の範囲(英語) [claim1]
1. A substantially pure polypeptide comprising a fragment of SEQ ID NO:8, wherein the fragment has a cytidine deaminase activity.
[claim2]
2. A substantially pure polypeptide that is at least 95% identical to SEQ ID NO:8, wherein the polypeptide has a cytidine deaminase activity.
[claim3]
3. A substantially pure polypeptide encoded by a nucleic acid comprising a nucleotide sequence that is at least 95% identical to the coding sequence of SEQ ID NO:7, wherein the polypeptide has a cytidine deaminase activity.
[claim4]
4. A substantially pure polypeptide encoded by a nucleic acid that hybridizes to a probe, the sequence of which consists of the complement of the coding sequence of SEQ ID NO:7, in 0.9% NaCl at 75 deg. C., wherein the polypeptide has a cytidine deaminase activity.
[claim5]
5. A substantially pure polypeptide comprising an amino acid sequence wherein 1 to 10 amino acids in the amino acid sequence of SEQ ID NO:8 are substituted, deleted, and/or modified, or an amino acid sequence where 1 to 10 amino acids are added to the amino acid sequence of SEQ ID NO:8, wherein the polypeptide has a cytidine deaminase activity.
[claim6]
6. A substantially pure polypeptide comprising the amino acid sequence of SEQ ID NO:8.
[claim7]
7. A substantially pure polypeptide consisting of the amino acid sequence of SEQ ID NO:8.
  • 発明者/出願人(英語)
  • HONJO TASUKU
  • MURAMATSU MASAMICHI
  • KYOTO UNIVERSITY
  • MASAMICHI MURAMATSU
国際特許分類(IPC)
米国特許分類/主・副
  • C07K016/40
  • C12N009/78
上記の特許・技術に関心のある方は、下記「問合せ先」まで直接お問い合わせください。

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