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Cytidine deaminase

Foreign code F080001883
File No. F080001883
Posted date Jun 27, 2008
Country United States of America
Application number 88487804
Gazette No. 20050054073
Gazette No. 7083966
Date of filing Jul 2, 2004
Gazette Date Mar 10, 2005
Gazette Date Aug 1, 2006
International application number JP2000001918
International publication number WO2000058480
Date of international filing Mar 28, 2000
Date of international publication Oct 5, 2000
Priority data
  • P1999-087192 (Mar 29, 1999) JP
  • P1999-178999 (Jun 24, 1999) JP
  • P1999-371382 (Dec 27, 1999) JP
  • 2000WO-JP01918 (Mar 28, 2000) WO
  • 2001US-09966880 (Sep 28, 2001) US
Title Cytidine deaminase
Abstract (US7083966)
Genes encoding novel proteins named AID (Activation-Induced cytidine Deaminase) are described.
The AID proteins are structurally related to APOBEC-1, an RNA editing enzyme, and have a cytidine deaminase activity similar to APOBEC-1.
The AID genes were found by preparing cDNA libraries from mouse B cell clone CH12F3-2 (which undergoes class switch recombination from IgM to IgA at an extremely high rate after activation of the cells by stimulation with cytokines), with and without stimulation with cytokines, and performing subtraction cloning using the libranes.
Scope of claims [claim1]
1. A substantially pure polypeptide comprising a fragment of SEQ ID NO:8, wherein the fragment has a cytidine deaminase activity.
[claim2]
2. A substantially pure polypeptide that is at least 95% identical to SEQ ID NO:8, wherein the polypeptide has a cytidine deaminase activity.
[claim3]
3. A substantially pure polypeptide encoded by a nucleic acid comprising a nucleotide sequence that is at least 95% identical to the coding sequence of SEQ ID NO:7, wherein the polypeptide has a cytidine deaminase activity.
[claim4]
4. A substantially pure polypeptide encoded by a nucleic acid that hybridizes to a probe, the sequence of which consists of the complement of the coding sequence of SEQ ID NO:7, in 0.9% NaCl at 75 deg. C., wherein the polypeptide has a cytidine deaminase activity.
[claim5]
5. A substantially pure polypeptide comprising an amino acid sequence wherein 1 to 10 amino acids in the amino acid sequence of SEQ ID NO:8 are substituted, deleted, and/or modified, or an amino acid sequence where 1 to 10 amino acids are added to the amino acid sequence of SEQ ID NO:8, wherein the polypeptide has a cytidine deaminase activity.
[claim6]
6. A substantially pure polypeptide comprising the amino acid sequence of SEQ ID NO:8.
[claim7]
7. A substantially pure polypeptide consisting of the amino acid sequence of SEQ ID NO:8.
  • Inventor, and Inventor/Applicant
  • HONJO TASUKU
  • MURAMATSU MASAMICHI
  • KYOTO UNIVERSITY
  • MASAMICHI MURAMATSU
IPC(International Patent Classification)
U.S. Cl./(Sub)
  • C07K016/40
  • C12N009/78
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