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Cytidine deaminase

Foreign code F080001884
File No. F080001884
Posted date Jun 27, 2008
Country United States of America
Application number 96688001
Gazette No. 20020164743
Gazette No. 6815194
Date of filing Sep 28, 2001
Gazette Date Nov 7, 2002
Gazette Date Nov 9, 2004
Priority data
  • P1999-087192 (Mar 29, 1999) JP
  • P1999-178999 (Jun 24, 1999) JP
  • P1999-371382 (Dec 27, 1999) JP
Title Cytidine deaminase
Abstract Genes encoding novel proteins named AID (Activation-Induced cytidine Deaminase), that are structurally related to APOBEC-1, an RNA editing enzyme, and have a cytidine deaminase activity similar to APOBEC-1, have been found by preparing cDNA libraries from mouse B cell clone CH12F3-2 (which undergoes class switch recombination from IgM to IgA at an extremely high rate after activation of the cells by stimulation with cytokines), with and without stimulation with cytokines, and performing subtraction cloning using the libraries.
  • Inventor, and Inventor/Applicant
  • Tasuku Honjo
  • Masamichi Muramatsu
  • Takeda Chemical Industries, Ltd.
IPC(International Patent Classification)
U.S. Cl./(Sub)
  • 435/227
  • 435/069.1
  • 435/252.3
  • 435/252.33
  • 435/320.1
  • 435/348
  • 435/254.2
  • 435/325
  • 435/195
  • 536/023.2
  • 536/023.1
  • 536/024.3
  • 536/024.31
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