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NOVEL CULTURED SILKWORM CELL ENABLING HIGHLY EFFICIENT BACULOVIRUS PRODUCTION AND PROTEIN PRODUCTION

Foreign code F080001904
File No. QP050139-PC
Posted date Aug 22, 2008
Country WIPO
International application number 2007JP059028
International publication number WO 2007/125982
Date of international filing Apr 26, 2007
Date of international publication Nov 8, 2007
Priority data
  • P2006-122943 (Apr 27, 2006) JP
Title NOVEL CULTURED SILKWORM CELL ENABLING HIGHLY EFFICIENT BACULOVIRUS PRODUCTION AND PROTEIN PRODUCTION
Abstract None of the existing silkworm-origin cultured cells has a sufficiently high BmNPV growth efficiency. In a system with the use of such existing silkworm-origin cultured cells, therefore, it takes a long time to construct a recombinant virus and a virus solution with a high titer cannot be produced. Under these circumstances, it is intended to provide a cell line Bme21 (FERM P-20852), which originates in silkworm embryo and is highly sensitive to BmNPV, or a variant thereof having the biologically equivalent properties thereto. It is also intended to provide a method of producing a recombinant virus, a method of producing a recombinant protein, a method of elevating the efficiency in the production of a recombinant virus and a method of elevating the efficiency in the production of a recombinant protein each using the cell line Bme21 or a variant thereof.
Scope of claims (In Japanese)
【請求項1】カイコ胚由来であり、BmNPV高感受性である細胞株 Bme21(FERM P-20852)又はそれと同一の生物学的特性を有するその変異体。

【請求項2】カイコ系統e21の胚の初代培養から得られる、BmNPV高感受性細胞株。

【請求項3】請求項1又は2に記載の細胞株又はその変異体を用いる、組換えウイルスの生産方法。

【請求項4】請求項1又は2に記載の細胞株又はその変異体を用いる、組換えタンパク質の生産方法。

【請求項5】請求項1又は2に記載の細胞株又はその変異体を用いる、組換えウイルス生産の効率化方法。

【請求項6】請求項1又は2に記載の細胞株又はその変異体を用いる、組換えタンパク質生産の効率化方法。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • Kyushu University, National University Corporation
  • Inventor
  • Kusakabe, Takahiro
  • Aoki, Tisa
  • Ninagi, Osamu
  • Lee, Jae Man
  • Iiyama, Kazuhiro
  • Kawakami, Naoya
IPC(International Patent Classification)
Specified countries AE AG AL AM AT AU AZ BA BB BE BF BG BH BJ BR BW BY BZ CA CF CG CH CI CM CN CO CR CU CY CZ DE DK DM DZ EC EE EG ES FI FR GA GB GD GE GH GM GN GQ GR GT GW HN HR HU ID IE IL IN IS IT JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LV LY MA MC MD MG MK ML MN MR MT MW MX MY MZ NA NE NG NI NL NO NZ OM PG PH PL PT RO RS RU SC SD SE SG SI SK SL SM SN SV SY SZ TD TG TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
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