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PERITONEUM-PROTECTING AGENT AND METHOD FOR PRODUCING PERITONEUM-PROTECTING AGENT

Foreign code F100002254
Posted date Sep 28, 2010
Country WIPO
International application number 2010JP002865
International publication number WO 2010/122787
Date of international filing Apr 21, 2010
Date of international publication Oct 28, 2010
Priority data
  • P2009-104704 (Apr 23, 2009) JP
Title PERITONEUM-PROTECTING AGENT AND METHOD FOR PRODUCING PERITONEUM-PROTECTING AGENT
Abstract Provided are a method for easily collecting a sufficient amount of peritoneal mesothelial cells and the collected peritoneal mesothelial cells. Also provided is a peritoneum-protecting agent which comprises said peritoneal mesothelial cells as the active ingredient, or a material for regenerative medicine which comprises said peritoneum-protecting agent. A sufficient amount of peritoneal mesothelial cells can be easily collected by selecting epithelioid-shaped cells, either morphologically or using a marker that is expressed on the cell surface as an indication, from among cells in a peritoneal dialysis waste fluid obtained from a patient undergoing peritoneal dialysis. The peritoneal mesothelial cells thus obtained exert peritoneum-protecting effects, i.e., effects of protecting the peritoneum from adhesion, thickening, damages and so on, and, therefore, can be used as a peritoneum-protecting agent or a material for regenerative medicine.
Scope of claims (In Japanese)
【請求項1】腹膜透析排液から回収した腹膜中皮細胞を有効成分として含む、腹膜保護剤。

【請求項2】腹膜透析排液から回収した腹膜中皮細胞を1mlあたり少なくとも10個含む、請求項1に記載の腹膜保護剤。

【請求項3】腹膜透析排液から回収した腹膜中皮細胞が、上皮様形態細胞である請求項1または2に記載の腹膜保護剤。

【請求項4】上皮様形態細胞が、肝細胞増殖因子(HGF)を発現してなる請求項3に記載の腹膜保護剤。

【請求項5】腹膜保護が、腹膜癒着形成、腹膜肥厚および/または腹膜損傷に対する保護である、請求項1~4のいずれか1に記載の腹膜保護剤。

【請求項6】採取した腹膜透析排液から細胞を回収し、さらに上皮様形態細胞を選別する工程を含む請求項1~5のいずれか1に記載の腹膜保護剤の調製方法。

【請求項7】前記上皮様形態細胞の選別が、腹膜透析排液から回収された細胞を培養し、形態学的に上皮様形態細胞と認められる細胞を選別することによる請求項6に記載の腹膜保護剤の調製方法。

【請求項8】前記上皮様形態細胞の選別が、腹膜透析排液から回収された細胞について、上皮様形態細胞に特異的に発現されるマーカーを指標として選別することによる請求項6に腹膜保護剤の調製方法。

【請求項9】上皮様形態細胞に特異的に発現されるマーカーが肝細胞増殖因子(HGF)である請求項8に腹膜保護剤の調製方法。

【請求項10】採取した腹膜透析排液から細胞を回収し、さらに上皮様形態細胞を選別する工程を含む腹膜中皮細胞の採取方法。

【請求項11】請求項10の方法により採取された腹膜中皮細胞。

【請求項12】請求項11に記載の腹膜中皮細胞を含む腹膜保護剤。

【請求項13】請求項1~5および請求項12のいずれか1に記載の腹膜保護剤を含む再生医療用材料。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
  • Inventor
  • KITAMURA, Shinji
  • SUGIYAMA, Hitoshi
  • MAKINO, Hirofumi
IPC(International Patent Classification)
Specified countries AE(UTILITY MODEL),AG,AL(UTILITY MODEL),AM(PROVISIONAL PATENT)(UTILITY MODEL),AO(UTILITY MODEL),AT(UTILITY MODEL),AU,AZ(UTILITY MODEL),BA,BB,BG(UTILITY MODEL),BH(UTILITY MODEL),BR(UTILITY MODEL),BW,BY(UTILITY MODEL),BZ(UTILITY MODEL),CA,CH,CL(UTILITY MODEL),CN(UTILITY MODEL),CO(UTILITY MODEL),CR(UTILITY MODEL),CU(INVENTOR'S CERTIFICATE),CZ(UTILITY MODEL),DE(UTILITY MODEL),DK(UTILITY MODEL),DM,DO(UTILITY MODEL),DZ,EC(UTILITY MODEL),EE(UTILITY MODEL),EG(UTILITY MODEL),ES(UTILITY MODEL),FI(UTILITY MODEL),GB,GD,GE(UTILITY MODEL),GH(UTILITY CERTIFICATE),GM,GT(UTILITY MODEL),HN(UTILITY MODEL),HR(CONSENSUAL PATENT),HU(UTILITY MODEL),ID,IL,IN,IS,JP(UTILITY MODEL),KE(UTILITY MODEL),KG(UTILITY MODEL),KM,KN,KP(INVENTOR'S CERTIFICATE)(UTILITY MODEL),KR(UTILITY MODEL),KZ(PROVISIONAL PATENT)(UTILITY MODEL),LA,LC,LK,LR,LS(UTILITY MODEL),LT,LU,LY,MA,MD(UTILITY MODEL),ME,MG,MK,MN,MW,MX(UTILITY MODEL),MY(UTILITY-INNOVATION),MZ(UTILITY MODEL),NA,NG,NI(UTILITY MODEL),NO,NZ,OM(UTILITY MODEL),PE(UTILITY MODEL),PG,PH(UTILITY MODEL),PL(UTILITY MODEL),PT(UTILITY MODEL),RO,RS(PETTY PATENT),RU(UTILITY MODEL),SC,SD,SE,SG,SK(UTILITY MODEL),SL(UTILITY MODEL),SM,ST,SV(UTILITY MODEL),SY,TH(PETTY PATENT),TJ(UTILITY MODEL),TM(PROVISIONAL PATENT),TN,TR(UTILITY MODEL),TT(UTILITY CERTIFICATE),TZ,UA(UTILITY MODEL),UG(UTILITY CERTIFICATE),US,UZ(UTILITY MODEL),VC(UTILITY CERTIFICATE),VN(PATENT FOR UTILITY SOLUTION),ZA,ZM,ZW,EP(AT,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LT,LU,LV,MC,MK,MT,NL,NO,PL,PT,RO,SE,SI,SK,SM,TR),OA(BF(UTILITY MODEL),BJ(UTILITY MODEL),CF(UTILITY MODEL),CG(UTILITY MODEL),CI(UTILITY MODEL),CM(UTILITY MODEL),GA(UTILITY MODEL),GN(UTILITY MODEL),GQ(UTILITY MODEL),GW(UTILITY MODEL),ML(UTILITY MODEL),MR(UTILITY MODEL),NE(UTILITY MODEL),SN(UTILITY MODEL),TD(UTILITY MODEL),TG(UTILITY MODEL)),AP(BW(UTILITY MODEL),GH(UTILITY MODEL),GM(UTILITY MODEL),KE(UTILITY MODEL),LR(UTILITY MODEL),LS(UTILITY MODEL),MW(UTILITY MODEL),MZ(UTILITY MODEL),NA(UTILITY MODEL),SD(UTILITY MODEL),SL(UTILITY MODEL),SZ(UTILITY MODEL),TZ(UTILITY MODEL),UG(UTILITY MODEL),ZM(UTILITY MODEL),ZW(UTILITY MODEL)),EA(AM,AZ,BY,KG,KZ,MD,RU,TJ,TM)

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