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METHOD FOR DETERMINING THERAPEUTIC EFFECT OF REPERFUSION THERAPY commons

Foreign code F100002350
Posted date Dec 15, 2010
Country WIPO
International application number 2009JP069224
International publication number WO 2010/055867
Date of international filing Nov 11, 2009
Date of international publication May 20, 2010
Priority data
  • P2008-289118 (Nov 11, 2008) JP
Title METHOD FOR DETERMINING THERAPEUTIC EFFECT OF REPERFUSION THERAPY commons
Abstract Disclosed is a method for simply and rapidly determining whether a reperfusion therapy given to a subject is effective or not. The blood collected from a subject who has received a reperfusion therapy is contacted with an antibody capable of recognizing ADAMTS, and a complex produced as the result of the contact is detected. It can be determined whether the reperfusion therapy is effective or not by comparing the ADAMTS level in the blood collected before the reperfusion therapy is provided with that in the blood collected after the reperfusion therapy is provided.
Scope of claims (In Japanese)
【請求項1】 下記の工程:
(1)再灌流治療を施した対象由来の血液と、ADAMTSを認識する抗体とを接触させる工程;および
(2)上記工程(1)で形成された複合体を検出する工程
を含むことを特徴とする、再灌流治療効果を判定する方法。

【請求項2】 ADAMTSが、ADAMTS-1である、請求項1に記載の方法。

【請求項3】 抗体がモノクローナル抗体である、請求項1または2に記載の方法。

【請求項4】 再灌流治療の対象疾患が、急性虚血性疾患である、請求項1~3のいずれか一項に記載の方法。

【請求項5】 ADAMTS-1を認識する抗体を含む、再灌流治療効果判定用キット。

【請求項6】 ADAMTS-1を認識する抗体を有効成分とする、再灌流治療効果検査薬。

【請求項7】 抗体がモノクローナル抗体である、請求項5または6に記載のキットまたは検査薬。

【請求項8】 再灌流治療の対象疾患が、急性虚血性疾患である、請求項5~7のいずれか一項に記載のキットまたは検査薬。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • National University Corporation Okayama University
  • Inventor
  • HIROHATA, Satoshi
  • USUI, Shinichi
  • KUSACHI, Shozo
IPC(International Patent Classification)
Specified countries AE(UTILITY MODEL),AG,AL(UTILITY MODEL),AM(PROVISIONAL PATENT)(UTILITY MODEL),AO(UTILITY MODEL),AT(UTILITY MODEL),AU,AZ(UTILITY MODEL),BA,BB,BG(UTILITY MODEL),BH(UTILITY MODEL),BR(UTILITY MODEL),BW(UTILITY MODEL),BY(UTILITY MODEL),BZ(UTILITY MODEL),CA,CH,CL(UTILITY MODEL),CN(UTILITY MODEL),CO(UTILITY MODEL),CR(UTILITY MODEL),CU(INVENTOR'S CERTIFICATE),CZ(UTILITY MODEL),DE(UTILITY MODEL),DK(UTILITY MODEL),DM,DO(UTILITY MODEL),DZ,EC(UTILITY MODEL),EE(UTILITY MODEL),EG(UTILITY MODEL),ES(UTILITY MODEL),FI(UTILITY MODEL),GB,GD,GE(UTILITY MODEL),GH(UTILITY CERTIFICATE),GM,GT(UTILITY MODEL),HN,HR(CONSENSUAL PATENT),HU(UTILITY MODEL),ID,IL,IN,IS,JP(UTILITY MODEL),KE(UTILITY MODEL),KG(UTILITY MODEL),KM,KN,KP(INVENTOR'S CERTIFICATE)(UTILITY MODEL),KR(UTILITY MODEL),KZ(PROVISIONAL PATENT)(UTILITY MODEL),LA,LC,LK,LR,LS(UTILITY MODEL),LT,LU,LY,MA,MD(UTILITY MODEL),ME,MG,MK,MN,MW,MX(UTILITY MODEL),MY(UTILITY-INNOVATION),MZ(UTILITY MODEL),NA,NG,NI(UTILITY MODEL),NO,NZ,OM(UTILITY MODEL),PE(UTILITY MODEL),PG,PH(UTILITY MODEL),PL(UTILITY MODEL),PT(UTILITY MODEL),RO,RS(PETTY PATENT),RU(UTILITY MODEL),SC,SD,SE,SG,SK(UTILITY MODEL),SL(UTILITY MODEL),SM,ST,SV(UTILITY MODEL),SY,TJ(UTILITY MODEL),TM(PROVISIONAL PATENT),TN,TR(UTILITY MODEL),TT(UTILITY CERTIFICATE),TZ,UA(UTILITY MODEL),UG(UTILITY CERTIFICATE),US,UZ(UTILITY MODEL),VC(UTILITY CERTIFICATE),VN(PATENT FOR UTILITY SOLUTION),ZA,ZM,ZW,EP(AT,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LT,LU,LV,MC,MK,MT,NL,NO,PL,PT,RO,SE,SI,SK,SM,TR),OA(BF(UTILITY MODEL),BJ(UTILITY MODEL),CF(UTILITY MODEL),CG(UTILITY MODEL),CI(UTILITY MODEL),CM(UTILITY MODEL),GA(UTILITY MODEL),GN(UTILITY MODEL),GQ(UTILITY MODEL),GW(UTILITY MODEL),ML(UTILITY MODEL),MR(UTILITY MODEL),NE(UTILITY MODEL),SN(UTILITY MODEL),TD(UTILITY MODEL),TG(UTILITY MODEL)),AP(BW(UTILITY MODEL),GH(UTILITY MODEL),GM(UTILITY MODEL),KE(UTILITY MODEL),LS(UTILITY MODEL),MW(UTILITY MODEL),MZ(UTILITY MODEL),NA(UTILITY MODEL),SD(UTILITY MODEL),SL(UTILITY MODEL),SZ(UTILITY MODEL),TZ(UTILITY MODEL),UG(UTILITY MODEL),ZM(UTILITY MODEL),ZW(UTILITY MODEL)),EA(AM,AZ,BY,KG,KZ,MD,RU,TJ,TM)

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