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BIOMARKER FOR ALLERGIC DISEASE AND UTILIZATION OF THE SAME

外国特許コード F110002368
掲載日 2011年1月13日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2008JP073175
国際公開番号 WO 2009081854
国際出願日 平成20年12月19日(2008.12.19)
国際公開日 平成21年7月2日(2009.7.2)
優先権データ
  • 特願2007-330025 (2007.12.21) JP
発明の名称 (英語) BIOMARKER FOR ALLERGIC DISEASE AND UTILIZATION OF THE SAME
発明の概要(英語) It is intended to provide a biomarker for an allergic disease caused by an allergic reaction that is caused not exclusively by histamine release such as itching, and utilization of the same. Use of Granzyme A as a biomarker makes it possible to provide an indication for an intractable itching skin disease, for which the existing antiallergic drugs are little efficacious, and easily and adequately make a diagnosis of the disease. Also, it makes possible to, for example, make a diagnosis of an allergic disease with an IV type allergy-like reaction not depending on the antigen-antibody reaction system. Screening with the use of Granzyme A enables the development of a novel remedy for an allergic disease. Moreover, a drug capable of specifically controlling the action of a granzyme enables treatment for an allergic disease with little side effect.
従来技術、競合技術の概要(英語) BACKGROUND ART
Itch, cause the urge to shave the user interface of human experience will be readily appreciated. However, 'the classic mouse histamine-induced pruritus (histamine) substance to an animal such as scraping operation does not cause', 'chronic pain rat adjuvant arthritis model animal of cleaning operation of the analgesic is repressed' or the like, of cleaning operation is not necessarily human itching animal indicia are regarded as not been. Mouse back skin (neck close to the rostral portion) of the material and the light emitting material is raised to the injection pain pruritus, pruritus of the strain cause the scrapping using hind limb only material operation, becomes an index of itching scraping operation (non-patent document 1). Humans, most portions of the body can be hand paddling. However, in a case where the mouse hind paw paddling. Mice, chewing and stimulation to the hind leg shows the response of itching, pain stimulation (non-patent document 2) licking the reaction.
In a number of human and mosquito bites to feel strong itching. Itch and pierce the skin reaction by mosquitoes, which is believed to be the allergic reaction. Pierce the mosquitoes of the first operation is to shave the mouse causes less, at a frequency of once a week 1 repeated penetration and 2 mosquitoes, scraping operation gradually increases. Repeated injections of mosquito salivary gland extract is gradually increased in the scraping operation. The extraneous operation increase, in mast cell deficient mice (mast cells) is also observed. In addition, in sensitized mice, vascular leak is by inserting a plasma mosquito H1 is suppressed by a histamine receptor blocker, scraping operation is not suppressed. That is, itching of the skin due to an allergy is immediate, mechanisms other than those based on mast cell histamine - (non-patent document 3) is important. Repeated injections of mosquito salivary gland extract of cleaning operation is an increase in the mouse, anti-allergic action upon having various allergy therapeutic agent is suppressed by azelastine, H1 histamine receptor blocker of terfenadine and the steroid dexamethasone is not suppressed. In addition, the mosquito salivary gland extract sensitized mice injected, an increase in the activity of primary afferent fibers. Which prevents the reaction azelastine, terfenadine (non-patent document 4) is not suppressed.
Eur. J. Pharmacol., 275: 229-233 (1995)
Pain Res., 14: 53-59 (1999)
Jpn. J. Pharmacol., 86: 97-105 (2001)
J. Pharmacol. Sci., 91: 263-266 (2003)
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • UNIVERSITY OF TOYAMA
  • 発明者(英語)
  • ANDOH, Tsugunobu
  • KURAISHI, Yasushi
  • NAKANO, Tasuku
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PG PH PL PT RO RS RU SC SD SE SG SK SL SM ST SV SY TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ MD RU TJ TM
EPO: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MT NL NO PL PT RO SE SI SK TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
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