TOP > 外国特許検索 > Bone marrow-directing drug delivery materials and their applications

Bone marrow-directing drug delivery materials and their applications UPDATE

外国特許コード F110002409
整理番号 100-EP
掲載日 2011年2月3日
出願国 欧州特許庁(EPO)
出願番号 06747265
公報番号 1906924
公報番号 1906924
出願日 平成18年6月5日(2006.6.5)
公報発行日 平成20年4月9日(2008.4.9)
公報発行日 平成30年5月2日(2018.5.2)
国際出願番号 JP2006311676
国際公開番号 WO2006132388
国際出願日 平成18年6月5日(2006.6.5)
国際公開日 平成18年12月14日(2006.12.14)
優先権データ
  • 特願2005-165763 (2005.6.6) JP
  • 2006WO-JP311676 (2006.6.5) WO
発明の名称 (英語) Bone marrow-directing drug delivery materials and their applications UPDATE
発明の概要(英語) (EP1906924)
The present invention pertains to a bone marrow-directing drug delivery material that includes at least one fine particle, wherein the fine particle includes an anionic moiety on a surface of the particle.
Also disclosed are uses of the material set forth herein for the prevention, treatment, or diagnosis of a disease of bone, cartilage, bone marrow, or a joint.
Also disclosed are methods of preventing, treating, or diagnosing a disease of bone, cartilage, bone marrow, or a joint in a subject, involving administering to the subject a pharmaceutically effective amount of the material of the present invention.
特許請求の範囲(英語) [claim1]
1. A drug delivery material for use in targeting bone marrow, the material comprising at least one fine particle comprising: - (1) an anionic moiety on the surface of the particle, said anionic moiety being a carboxylic acid group represented by formula (2):

HOOCR **3-CO-HNCH(COOR **4)CH 2CH 2COOR **4

wherein R **3 represents-CH 2CH 2- or -CH(CH 3)CH 2-, and R **4 represents a C 12 - C 22 alkyl group; and - (2) a water soluble polymer being a polyethylene glycol
and wherein the at least one fine particle further comprises a drug bound to the at least one fine particle.
[claim2]
2. The material of claim 1, wherein the fine particle has a diameter of 0.02 to 5 micron m, in particular wherein the material is further defined as comprising a plurality of fine particles with an average diameter of 0.02 to 5 micron m.
[claim3]
3. The material of any of claims 1 to 2, wherein the at least one fine particle is defined as comprising a water soluble polymer, in particular wherein the water soluble polymer is bound to a surface of at least one fine particle wherein the water soluble polymer is polyethylene glycol, the material preferably comprising: a) 1 to 50 mol% of an amphipathic compound of formula (2):

HOOCR **3-CO-HNCH(COOR **4)CH 2CH 2COOR **4

wherein R **3 is -CH 2CH 2- and R **4 is a C 10 - C 22 alkyl group, and b) 0.5 to 4.8 mol% of an amphipathic compound comprising polyethylene glycol as its hydrophilic portion, wherein at least one fine particle has an average particle diameter of 100 to 500 nm.
[claim4]
4. The material of any of claims 1 to 3, wherein at least one fine particle further comprise a drug bound to the at least one fine particle.
[claim5]
5. The material according to any of claims 1 to 4 for use in the prevention, treatment, or diagnosis of a disease of bone, of cartilage, of a joint, or of bone marrow.
[claim6]
6. The material for use according to claim 5, wherein the pharmaceutical is in a dosage form allowing administration of the material in an amount of 0.1 to 500 mg per kg of body weight.
[claim7]
7. The material for use according to claim 5 or 6, wherein the pharmaceutical is for administration to a human.
  • 出願人(英語)
  • UNIVERSITY OF TEXAS
  • WASEDA UNIVERSITY
  • 発明者(英語)
  • SOU KEITARO
  • TAKEOKA SHINJI
  • TSUCHIDA EISHUN
  • GOINS BETH A
  • PHILLIPS WILLIAM T
国際特許分類(IPC)
指定国 (EP1906924)
Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
技術導入、技術提携、実用化開発(受託研究・共同研究等)のご相談を承っております。お気軽にご連絡ください。

PAGE TOP

close
close
close
close
close
close