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Bone marrow-directing drug delivery materials and their applications

Foreign code F110002410
File No. 100-US
Posted date Feb 3, 2011
Country United States of America
Application number 91664806
Gazette No. 20090297608
Gazette No. 8916197
Date of filing Jun 5, 2006
Gazette Date Dec 3, 2009
Gazette Date Dec 23, 2014
International application number JP2006311676
International publication number WO2006132388
Date of international filing Jun 5, 2006
Date of international publication Dec 14, 2006
Priority data
  • P2005-165763 (Jun 6, 2005) JP
  • 2006WO-JP311676 (Jun 5, 2006) WO
Title Bone marrow-directing drug delivery materials and their applications
Abstract (US8916197)
The present invention pertains to a bone marrow-directing drug delivery material that includes at least one fine particle, wherein the fine particle includes an anionic moiety on a surface of the particle.
Also disclosed are uses of the material set forth herein for the prevention, treatment, or diagnosis of a disease of bone, cartilage, bone marrow, or a joint.
Also disclosed are methods of preventing, treating, or diagnosing a disease of bone, cartilage, bone marrow, or a joint in a subject, involving administering to the subject a pharmaceutically effective amount of the material of the present invention.
Scope of claims [claim1]
1. A bone marrow-directing drug delivery material comprising at least one fine particle having a diameter of 20 to 500 nm, wherein the fine particle further comprises: a first amphipathic compound having the following structure:
MOOCR3 -- CO -- HNCH(COOR4)CH2CH2COOR4,
wherein M is a hydrogen atom or a monovalent cation, R3 is -- CH2CH2 -- and R4 is a C10-C22 alkyl group; and
a second amphipathic compound comprising 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[monomethoxy poly(ethylene glycol) (PEG-DSPE).
[claim2]
2. The material of claim 1, wherein the fine particle has a diameter of 100 to 500 nm.
[claim3]
3. The material of claim 1, wherein the particle is further defined as an aggregate of amphipathic molecules that form a vesicle.
[claim4]
4. The material of claim 1, wherein: the first amphipathic compound is present at 1 to 50 mol %, and wherein the second amphipathic compound is present at 0.5 to 4.8 mol %.
[claim5]
5. The material of claim 1, wherein at least one fine particle further comprises a drug bound to the at least one fine particle.
[claim6]
6. A method of preventing, treating, or diagnosing a disease of bone, cartilage, a joint, or bone marrow in a subject, comprising administering to the subject a pharmaceutically effective amount of the material of claim 1.
[claim7]
7. The method of claim 6, wherein the pharmaceutically effective amount of the material is 0.1 to 500 mg of the material per kg of body weight of the subject.
[claim8]
8. The method of claim 6, wherein the subject has a disease of bone marrow.
[claim9]
9. A method of preventing, treating, or diagnosing a joint disease in a subject, comprising administering to the subject a pharmaceutically effective amount of the material of claim 1.
[claim10]
10. The method of claim 9, wherein the pharmaceutically effective amount of the material is 0.1 to 500 mg of the material per kg of body weight of the subject.
[claim11]
11. The method of claim 1, wherein the subject is a human.
[claim12]
12. A kit comprising a predetermined amount of the material of claim 1 and a sealed container.
  • Inventor, and Inventor/Applicant
  • SOU KEITARO
  • TAKEOKA SHINJI
  • TSUCHIDA EISHUN
  • GOINS BETH A
  • PHILLIPS WILLIAM T
  • UNIVERSITY OF TEXAS
  • WASEDA UNIVERSITY
IPC(International Patent Classification)
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