Top > Search of International Patents > METHOD OF QUANTIFYING OXIDIZED PROTEIN, LABELING REAGENTS FOR QUANTIFYING OXIDIZED PROTEIN AND LABELING REAGENT KIT FOR QUANTIFYING OXIDIZED PROTEIN

METHOD OF QUANTIFYING OXIDIZED PROTEIN, LABELING REAGENTS FOR QUANTIFYING OXIDIZED PROTEIN AND LABELING REAGENT KIT FOR QUANTIFYING OXIDIZED PROTEIN

Foreign code F110002440
File No. S2006-0696-C0
Posted date Mar 4, 2011
Country WIPO
International application number 2007JP055617
International publication number WO 2007/111193
Date of international filing Mar 20, 2007
Date of international publication Oct 4, 2007
Priority data
  • P2006-077526 (Mar 20, 2006) JP
Title METHOD OF QUANTIFYING OXIDIZED PROTEIN, LABELING REAGENTS FOR QUANTIFYING OXIDIZED PROTEIN AND LABELING REAGENT KIT FOR QUANTIFYING OXIDIZED PROTEIN
Abstract An oxidized protein, which has been denatured by oxidation, is labeled with labeling reagents and quantified by mass spectrometry. In this process, a first labeling reagent, which is capable of reacting with the oxidized protein, and a second labeling reagent, which has the same chemical structure as the first labeling reagent and in which at least a part of the constituting atoms is substituted by an isotope of the atom concerned, are employed as the labeling agents. The oxidized protein labeled with the first labeling reagent and the oxidized protein labeled with the second labeling reagent are mixed together at various mixing ratios and subjected to mass spectrometry. As the labeling reagents, use is made of, for example, 2,4-dinitrophenylhydrazine and 2,4-dinitrophenylhydrazine in which a carbon atom in the phenyl group has been substituted by a stable isotope (13C).
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • Japan Advanced Institute of Science and Technology
  • Inventor
  • TSUJIMOTO, Kazuo
  • HAYASHI, Akio
  • KAWAI, Takaaki
  • MATSUMOTO, Hiroyuki
IPC(International Patent Classification)
Specified countries AE(UTILITY MODEL),AG,AL(UTILITY MODEL),AM(PROVISIONAL PATENT)(UTILITY MODEL),AT(UTILITY MODEL),AU,AZ(UTILITY MODEL),BA,BB,BG(UTILITY MODEL),BH,BR(UTILITY MODEL),BW,BY(UTILITY MODEL),BZ(UTILITY MODEL),CA,CH,CN(UTILITY MODEL),CO(UTILITY MODEL),CR(UTILITY MODEL),CU(INVENTOR'S CERTIFICATE),CZ(UTILITY MODEL),DE(UTILITY MODEL),DK(UTILITY MODEL),DM,DZ,EC(UTILITY MODEL),EE(UTILITY MODEL),EG(UTILITY MODEL),ES(UTILITY MODEL),FI(UTILITY MODEL),GB,GD,GE(UTILITY MODEL),GH,GM,GT,HN,HR(CONSENSUAL PATENT),HU(UTILITY MODEL),ID,IL,IN,IS,KE(UTILITY MODEL),KG(UTILITY MODEL),KM,KN,KP(INVENTOR'S CERTIFICATE)(UTILITY MODEL),KR(UTILITY MODEL),KZ(PROVISIONAL PATENT)(UTILITY MODEL),LA,LC,LK,LR,LS(UTILITY MODEL),LT,LU,LY,MA,MD(UTILITY MODEL),MG,MK,MN,MW,MX(UTILITY MODEL),MY(UTILITY-INNOVATION),MZ(UTILITY MODEL),NA,NG,NI(UTILITY MODEL),NO,NZ,OM,PG,PH(UTILITY MODEL),PL(UTILITY MODEL),PT(UTILITY MODEL),RO,RS(PETTY PATENT),RU(UTILITY MODEL),SC,SD,SE,SG,SK(UTILITY MODEL),SL(UTILITY MODEL),SM,SV,SY,TJ(UTILITY MODEL),TM(PROVISIONAL PATENT),TN,TR(UTILITY MODEL),TT(UTILITY CERTIFICATE),TZ,UA(UTILITY MODEL),UG(UTILITY CERTIFICATE),US,UZ(UTILITY MODEL),VC(UTILITY CERTIFICATE),VN,ZA,ZM,ZW,EP(AT,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HU,IE,IS,IT,LT,LU,LV,MC,MT,NL,PL,PT,RO,SE,SI,SK,TR),OA(BF(UTILITY MODEL),BJ(UTILITY MODEL),CF(UTILITY MODEL),CG(UTILITY MODEL),CI(UTILITY MODEL),CM(UTILITY MODEL),GA(UTILITY MODEL),GN(UTILITY MODEL),GQ(UTILITY MODEL),GW(UTILITY MODEL),ML(UTILITY MODEL),MR(UTILITY MODEL),NE(UTILITY MODEL),SN(UTILITY MODEL),TD(UTILITY MODEL),TG(UTILITY MODEL)),AP(BW,GH,GM,KE,LS,MW,MZ,NA,SD,SL,SZ,TZ,UG,ZM,ZW),EA(AM,AZ,BY,KG,KZ,MD,RU,TJ,TM)
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