Top > Search of International Patents > ANTI-VIRAL AGENT COMPRISING HETEROCYCLIC AROMATIC COMPOUND AS ACTIVE INGREDIENT

ANTI-VIRAL AGENT COMPRISING HETEROCYCLIC AROMATIC COMPOUND AS ACTIVE INGREDIENT

Foreign code F110002710
File No. S2008-0019-C0
Posted date Apr 8, 2011
Country WIPO
International application number 2008JP069122
International publication number WO 2009/054401
Date of international filing Oct 22, 2008
Date of international publication Apr 30, 2009
Priority data
  • P2007-279648 (Oct 26, 2007) JP
  • P2008-050771 (Feb 29, 2008) JP
Title ANTI-VIRAL AGENT COMPRISING HETEROCYCLIC AROMATIC COMPOUND AS ACTIVE INGREDIENT
Abstract Disclosed is an anti-viral agent comprising a compound represented by the formula (I) or (II) shown below or a pharmaceutically acceptable salt thereof. [Chemical formula 1] (I) wherein X represents CH, a nitrogen atom, an oxygen atom or a sulfur atom; Y and Z independently represent a nitrogen atom or C-R8, provided that at least one of Y and Z represents a nitrogen atom; and R1 to R8 independently represent a hydrogen atom, a linear C1-10-hydrocarbon group, a hydroxy group or a substituted or unsubstituted benzyl group; provided that R5 is not present when X represents an oxygen atom or a sulfur atom. [Chemical formula 2] (II) wherein X' represents CH or a nitrogen atom; Y' and Z' independently represent a nitrogen atom, N-R9 or C-R8, provided that at least one of Y' and Z' represents a nitrogen atom or N-R9; R1 to R4 and R6 to R8 are as defined above; R9 represents a hydrogen atom, a linear C1-10-hydrocarbon group, a hydroxy group or a substituted or unsubstituted benzyl group; and the ring C has the largest possible number of double bonds on the dotted lines.
Scope of claims (In Japanese)
【請求項1】次式(I):【化1】(式中、Xは、CH、窒素原子、酸素原子又は硫黄原子であり、Y及びZは、同一又は異なり、窒素原子又はC-R8であって、少なくとも一方は窒素原子であり、R1~R8は、同一又は異なり、水素原子、直鎖C1-10-炭化水素基、水酸基又は置換若しくは非置換のベンジル基であり、ただし、Xが酸素原子又は硫黄原子の場合には、R5は存在しない)、若しくは次式(II):【化2】(式中、X'は、CH又は窒素原子であり、Y'及びZ'は、同一又は異なり、窒素原子、N-R9又はC-R8であって、少なくとも一方は窒素原子又はN-R9であり、R1~R4及びR6~R8は、前記と同一であり、R9は、水素原子、直鎖C1-10-炭化水素基、水酸基又は置換若しくは非置換のベンジル基であり、C環は、点線部分に最多二重結合を有する)で示される化合物又はその薬学的に許容される塩を含有する抗ウイルス剤。

【請求項2】前記式(I)において、Xが窒素原子であり、YがC-R8であり、Zが窒素原子であり、R1~R8が同一又は異なり、水素原子又は直鎖C1-10-炭化水素基である化合物又はその薬学的に許容される塩を含有する、請求項1記載の抗ウイルス剤。

【請求項3】前記式(II)において、X'が窒素原子であり、Y'がC-R8であり、Z'がN-R9であり、R1~R4及びR6~R9が同一又は異なり、水素原子又は直鎖C1-10-炭化水素基である化合物又はその薬学的に許容される塩を含有する、請求項1記載の抗ウイルス剤。

【請求項4】前記直鎖C1-10-炭化水素基が直鎖C1-10-アルキル基である、請求項1~3のいずれか1項記載の抗ウイルス剤。

【請求項5】前記直鎖C1-10-アルキル基がメチル基である、請求項4記載の抗ウイルス剤。

【請求項6】前記ウイルスがフラビウイルス科に属するウイルスである、請求項1~5のいずれか1項記載の抗ウイルス剤。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • KAGOSHIMA UNIVERSITY
  • ONCOLYS BIOPHARMA, INC.
  • Inventor
  • BABA, Masanori
  • HASHIMOTO, Yuichi
  • AOYAMA, Hiroshi
  • SAKO, Kumiko
  • SATO, Shinichi
  • NAGAI, Katsuyuki
IPC(International Patent Classification)
Specified countries AE(UTILITY MODEL),AG,AL(UTILITY MODEL),AM(PROVISIONAL PATENT)(UTILITY MODEL),AO(UTILITY MODEL),AT(UTILITY MODEL),AU,AZ(UTILITY MODEL),BA,BB,BG(UTILITY MODEL),BH(UTILITY MODEL),BR(UTILITY MODEL),BW(UTILITY MODEL),BY(UTILITY MODEL),BZ(UTILITY MODEL),CA,CH,CN(UTILITY MODEL),CO(UTILITY MODEL),CR(UTILITY MODEL),CU(INVENTOR'S CERTIFICATE),CZ(UTILITY MODEL),DE(UTILITY MODEL),DK(UTILITY MODEL),DM(UTILITY MODEL),DO(UTILITY MODEL),DZ,EC(UTILITY MODEL),EE(UTILITY MODEL),EG(UTILITY MODEL),ES(UTILITY MODEL),FI(UTILITY MODEL),GB,GD,GE(UTILITY MODEL),GH(UTILITY CERTIFICATE),GM,GT(UTILITY MODEL),HN,HR(CONSENSUAL PATENT),HU(UTILITY MODEL),ID,IL,IN,IS,JP(UTILITY MODEL),KE(UTILITY MODEL),KG(UTILITY MODEL),KM,KN,KP(INVENTOR'S CERTIFICATE)(UTILITY MODEL),KR(UTILITY MODEL),KZ(PROVISIONAL PATENT)(UTILITY MODEL),LA,LC,LK,LR,LS(UTILITY MODEL),LT,LU,LY,MA,MD(UTILITY MODEL),ME(PETTY PATENT),MG,MK,MN,MW,MX(UTILITY MODEL),MY(UTILITY-INNOVATION),MZ(UTILITY MODEL),NA,NG,NI(UTILITY MODEL),NO,NZ,OM(UTILITY MODEL),PG,PH(UTILITY MODEL),PL(UTILITY MODEL),PT(UTILITY MODEL),RO,RS(PETTY PATENT),RU(UTILITY MODEL),SC,SD,SE,SG,SK(UTILITY MODEL),SL(UTILITY MODEL),SM,ST,SV(UTILITY MODEL),SY,TJ(UTILITY MODEL),TM(PROVISIONAL PATENT),TN,TR(UTILITY MODEL),TT(UTILITY CERTIFICATE),TZ,UA(UTILITY MODEL),UG(UTILITY CERTIFICATE),US,UZ(UTILITY MODEL),VC(UTILITY CERTIFICATE),VN(PATENT FOR UTILITY SOLUTION),ZA,ZM,ZW,EP(AT,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LT,LU,LV,MC,MT,NL,NO,PL,PT,RO,SE,SI,SK,TR),OA(BF(UTILITY MODEL),BJ(UTILITY MODEL),CF(UTILITY MODEL),CG(UTILITY MODEL),CI(UTILITY MODEL),CM(UTILITY MODEL),GA(UTILITY MODEL),GN(UTILITY MODEL),GQ(UTILITY MODEL),GW(UTILITY MODEL),ML(UTILITY MODEL),MR(UTILITY MODEL),NE(UTILITY MODEL),SN(UTILITY MODEL),TD(UTILITY MODEL),TG(UTILITY MODEL)),AP(BW(UTILITY MODEL),GH(UTILITY MODEL),GM(UTILITY MODEL),KE(UTILITY MODEL),LS(UTILITY MODEL),MW(UTILITY MODEL),MZ(UTILITY MODEL),NA(UTILITY MODEL),SD(UTILITY MODEL),SL(UTILITY MODEL),SZ(UTILITY MODEL),TZ(UTILITY MODEL),UG(UTILITY MODEL),ZM(UTILITY MODEL),ZW(UTILITY MODEL)),EA(AM,AZ,BY,KG,KZ,MD,RU,TJ,TM)
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