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ANTIBODY DIRECTED AGAINST CALCIFIED GLOBULE, AND USE THEREOF UPDATE

外国特許コード F110002874
整理番号 S2008-0413-C0
掲載日 2011年5月6日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2009JP061246
国際公開番号 WO 2009154283
国際出願日 平成21年6月19日(2009.6.19)
国際公開日 平成21年12月23日(2009.12.23)
優先権データ
  • 特願2008-162566 (2008.6.20) JP
  • 特願2008-308016 (2008.12.2) JP
  • 2009JP54475 (2009.3.9) WO
発明の名称 (英語) ANTIBODY DIRECTED AGAINST CALCIFIED GLOBULE, AND USE THEREOF UPDATE
発明の概要(英語) A calcified globule derived from renal/urinary calculus or an arteriosclerosis plaque derived from a carotid artery is immunized, and the screening is carried out on the calcified globule (NLO), thereby producing a specific antibody. The antibody can react specifically with an area where arteriosclerosis occurs (i.e., a calcified lesion area). A arteriosclerosis plaque (particularly a calcified lesion area) can be visualized by using a fluorescently labeled product of the antibody.
従来技術、競合技術の概要(英語) BACKGROUND ART
Monitoring of the states of arteriosclerosis diagnostic currently put into practical use as a method, the following 4 types of method are exemplified. 'Ankle brachial': in a state where the lateral arms, and measuring blood pressure of the feet, ankle normal a slightly high values. However if the blood vessel that is to say, from which the downstream blood pressure decreases, the ratio of the blood pressure of the ankle joint (ABI) on the upper/lower blood pressure. The reduction of ABI, lower limb arterial as well as, assume that the arteriosclerosis is systemic. 'Pulse wave velocity test': artery method for examining the hardness of the method for estimating the progression of arteriosclerosis. The resilient properties of the blood vessel is for healthy persons, the vibration is absorbed by the vessel wall, at a low speed of a pulse wave. With the progress of arteriosclerosis, the pulse wave can be faster, artery as an index of the progress of the curing speed can be estimated. 'Carotid ultrasound': running near the skin surface the internal state of the carotid artery is easy to observe since with ultrasonic waves, the carotid artery was examined, the progress of arteriosclerosis of a systemic method for estimating the. 'MR angiography (MRA) ': 'CT angiography (CTA) ' as a diagnostic image of vascular disease of conventional angiography is recently, less invasive than angiography approximately compared to the image information is so as to be used. CTA is an advantage of the high spatial resolution, (1) convenient inspection, (2) calcification, (3) and excellent in the detection of the lesions. The 'ankle brachial', 'pulse wave velocity test' is, at each position where the specific positions of the individual to atherosclerosis and for the diagnosis of the progress of cannot be, indirectly as a numerical value must be evaluated. In addition, 'carotid ultrasound' is, unlike a test of the pulse wave velocity, actually examine the inside of the vessel can supply the image directly as excellent. However, in the form of the ultrasound image of the vessel wall from gradation or since it is necessary to read status, inspection is carried out in a doctor or radiological technician skill required, of a portion excluding the carotid artery, at each position where the specific positions of the individual to atherosclerosis and for the diagnosis of the progress of cannot.
1998 Year can go, from human kidney stones Kajander and Ciftcioglu 'nanobacteria' "bacteria" that reported was separated (Nanobacteria: an alternative mechanism for pathogenic intra- and extracellular calcification and stone formation. Proc Natl Acad Sci U S A. 1998 Jul 7; 95 (14): 8274-9.). From the group of other U.S. NIH challenged "bacteria" and for an end user, as well as urinary tract (kidney) stone, the formation of globules NLO derived from calcification in the mechanism that is unknown in many cases.
It should be noted that, below a prior art document related to the present invention.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
  • MEDICAL AND BIOLOGICAL LABORATORIES CO., LTD.
  • 発明者(英語)
  • MATSUURA, Eiji
  • KUMON, Hiromi
  • KOJIMA, Kazuo
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PE PG PH PL PT RO RS RU SC SD SE SG SK SL SM ST SV SY TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ MD RU TJ TM
EPO: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

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