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NOVEL COMPOUND AND FUNCTIONAL LUMINESCENT PROBE COMPRISING SAME meetings

Foreign code F110002890
File No. S2008-0749-C0
Posted date May 9, 2011
Country WIPO
International application number 2009JP067919
International publication number WO 2010/044465
Date of international filing Oct 16, 2009
Date of international publication Apr 22, 2010
Priority data
  • P2008-269005 (Oct 17, 2008) JP
Title NOVEL COMPOUND AND FUNCTIONAL LUMINESCENT PROBE COMPRISING SAME meetings
Abstract Disclosed is a compound characterized by comprising a linker, an oxygen-concentration-responsive phosphorophore which is linked to a first end of the linker, and a fluorophore which is lined to a second end of the linker. In the compound, it is preferred that the triplet level of the phosphorophore be lower than that of the fluorophore. The compound can be used as an oxygen-responsive luminescent probe.
Scope of claims (In Japanese)
【請求項1】リンカーと、該リンカーの第1の端に結合した酸素濃度応答性りん光団と、該リンカーの第2の端に結合したけい光団とを含む化合物。

【請求項2】酸素濃度応答性りん光団の三重項準位が、けい光団の三重項準位よりも小さいことを特徴とする、請求項1に記載の化合物。

【請求項3】酸素濃度応答性りん光団がイリジウム錯体を含む基である、請求項1または2に記載の化合物。

【請求項4】イリジウム錯体が下記の構造を有する、請求項3に記載の化合物。
【化学式1】m、n、zが0~3の整数である。
XおよびYは 水素、またはアルキル基,アルコキシ基,アミノ基,ジメチルアミノ基,トリフルオロメチル基,シアノ基,アセチル基、カルボキシル基,アルキルエステル基,およびアルキルアミド基から選択される置換基を示す。

【請求項5】イリジウム錯体が下記いずれかの構造を有する、請求項3に記載の化合物。
【化学式2】

【請求項6】けい光団が下記いずれかの基を含む、請求項1~5のいずれか一項に記載の化合物。
【化学式3】

【請求項7】リンカーが下記の構造を含む、請求項1~6のいずれか一項に記載の化合物。
【化学式4】各環の炭素-炭素結合の1またはそれ以上は2重結合であってもよい。

【請求項8】リンカーがポリプロリンである、請求項1~6のいずれか一項に記載の化合物。

【請求項9】下記いずれかの化合物である、請求項1~8のいずれか一項に記載の化合物。
【化学式5】

【請求項10】 請求項1~9のいずれか一項に記載の化合物を含む酸素応答性発光プローブ。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
  • Inventor
  • TOBITA, Seiji
  • YOSHIHARA, Toshitada
  • HOSAKA, Masahiro
  • TAKEUCHI, Toshiyuki
IPC(International Patent Classification)
Specified countries AE(UTILITY MODEL),AG,AL(UTILITY MODEL),AM(PROVISIONAL PATENT)(UTILITY MODEL),AO(UTILITY MODEL),AT(UTILITY MODEL),AU,AZ(UTILITY MODEL),BA,BB,BG(UTILITY MODEL),BH(UTILITY MODEL),BR(UTILITY MODEL),BW(UTILITY MODEL),BY(UTILITY MODEL),BZ(UTILITY MODEL),CA,CH,CL(UTILITY MODEL),CN(UTILITY MODEL),CO(UTILITY MODEL),CR(UTILITY MODEL),CU(INVENTOR'S CERTIFICATE),CZ(UTILITY MODEL),DE(UTILITY MODEL),DK(UTILITY MODEL),DM,DO(UTILITY MODEL),DZ,EC(UTILITY MODEL),EE(UTILITY MODEL),EG(UTILITY MODEL),ES(UTILITY MODEL),FI(UTILITY MODEL),GB,GD,GE(UTILITY MODEL),GH(UTILITY CERTIFICATE),GM,GT(UTILITY MODEL),HN,HR(CONSENSUAL PATENT),HU(UTILITY MODEL),ID,IL,IN,IS,JP(UTILITY MODEL),KE(UTILITY MODEL),KG(UTILITY MODEL),KM,KN,KP(INVENTOR'S CERTIFICATE)(UTILITY MODEL),KR(UTILITY MODEL),KZ(PROVISIONAL PATENT)(UTILITY MODEL),LA,LC,LK,LR,LS(UTILITY MODEL),LT,LU,LY,MA,MD(UTILITY MODEL),ME,MG,MK,MN,MW,MX(UTILITY MODEL),MY(UTILITY-INNOVATION),MZ(UTILITY MODEL),NA,NG,NI(UTILITY MODEL),NO,NZ,OM(UTILITY MODEL),PE(UTILITY MODEL),PG,PH(UTILITY MODEL),PL(UTILITY MODEL),PT(UTILITY MODEL),RO,RS(PETTY PATENT),RU(UTILITY MODEL),SC,SD,SE,SG,SK(UTILITY MODEL),SL(UTILITY MODEL),SM,ST,SV(UTILITY MODEL),SY,TJ(UTILITY MODEL),TM(PROVISIONAL PATENT),TN,TR(UTILITY MODEL),TT(UTILITY CERTIFICATE),TZ,UA(UTILITY MODEL),UG(UTILITY CERTIFICATE),US,UZ(UTILITY MODEL),VC(UTILITY CERTIFICATE),VN(PATENT FOR UTILITY SOLUTION),ZA,ZM,ZW,EP(AT,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LT,LU,LV,MC,MK,MT,NL,NO,PL,PT,RO,SE,SI,SK,SM,TR),OA(BF(UTILITY MODEL),BJ(UTILITY MODEL),CF(UTILITY MODEL),CG(UTILITY MODEL),CI(UTILITY MODEL),CM(UTILITY MODEL),GA(UTILITY MODEL),GN(UTILITY MODEL),GQ(UTILITY MODEL),GW(UTILITY MODEL),ML(UTILITY MODEL),MR(UTILITY MODEL),NE(UTILITY MODEL),SN(UTILITY MODEL),TD(UTILITY MODEL),TG(UTILITY MODEL)),AP(BW(UTILITY MODEL),GH(UTILITY MODEL),GM(UTILITY MODEL),KE(UTILITY MODEL),LS(UTILITY MODEL),MW(UTILITY MODEL),MZ(UTILITY MODEL),NA(UTILITY MODEL),SD(UTILITY MODEL),SL(UTILITY MODEL),SZ(UTILITY MODEL),TZ(UTILITY MODEL),UG(UTILITY MODEL),ZM(UTILITY MODEL),ZW(UTILITY MODEL)),EA(AM,AZ,BY,KG,KZ,MD,RU,TJ,TM)
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