Top > Search of International Patents > OSTEOGENESIS PROMOTER COMPRISING [4-(METHYLTHIO)PHENYLTHIO]METHANEBISPHOSPHONIC ACID OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS ACTIVE INGREDIENT

OSTEOGENESIS PROMOTER COMPRISING [4-(METHYLTHIO)PHENYLTHIO]METHANEBISPHOSPHONIC ACID OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS ACTIVE INGREDIENT

Foreign code F110002976
File No. S2010-0512-N0
Posted date May 10, 2011
Country WIPO
International application number 2009JP003758
International publication number WO 2010/026701
Date of international filing Aug 5, 2009
Date of international publication Mar 11, 2010
Priority data
  • P2008-225484 (Sep 3, 2008) JP
Title OSTEOGENESIS PROMOTER COMPRISING [4-(METHYLTHIO)PHENYLTHIO]METHANEBISPHOSPHONIC ACID OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS ACTIVE INGREDIENT
Abstract Disclosed are: a compound which can be produced through a chemical synthesis at low cost, has an excellent osteogenesis-promoting activity, has high affinity for a bone, and can be applied without the need of any special DDS; and a method for promoting osteogenesis by administering the compound and applying the promotion of osteogenesis to the formation or regeneration of a bone. Specifically disclosed are: an osteogenesis promoter or a pharmaceutical composition comprising [4-(methylthio)phenylthio]methanebisphosphonic acid, which is one of bisphosphonic acids, or a pharmaceutically acceptable salt thereof as an active ingredient; and a method for promoting osteogenesis, which comprises administering the osteogenesis promoter or the pharmaceutical composition to a subject to be treated.
Scope of claims (In Japanese)
【請求項1】[(4-メチルチオ)フェニルチオ]メタンビスホスホン酸又は薬学的に許容され得るその塩を有効成分とする骨形成促進剤。

【請求項2】[(4-メチルチオ)フェニルチオ]メタンビスホスホン酸のナトリウム塩を有効成分とする骨形成促進剤。

【請求項3】[4-(メチルチオ)フェニルチオ]-メタンビスホスホン酸・2ナトリウム塩を有効成分とする骨形成促進剤。

【請求項4】有効成分がリン酸カルシウムから成る徐放剤に吸着されてなる、請求項1~3のいずれか一項に記載の骨形成促進剤。

【請求項5】リン酸カルシウムがα-トリカルシウムホスフェート、β-トリカルシウムホスフェート、オクタカルシウムホスフェート及びハイドロキシアパタイトから成る群から選択される、請求項4記載の骨形成促進剤。

【請求項6】請求項1~5のいずれか一項に記載の骨形成促進剤を含み、骨形成促進作用を有する医薬組成物。

【請求項7】水溶液の形態である、請求項6記載の医薬組成物。

【請求項8】注射液の形態を有する、請求項7に記載の医薬組成物。

【請求項9】請求項1~5のいずれか一項に記載の骨形成促進剤、又は、請求項6~8のいずれか一項に記載の医薬組成物を投与することから成る、骨形成促進方法。

【請求項10】請求項1~5のいずれか一項に記載の骨形成促進剤、又は、請求項6~8のいずれか一項に記載の医薬組成物を部位に局所投与することから成る、骨形成促進方法。

【請求項11】請求項1~5のいずれか一項に記載の骨形成促進剤、又は、請求項6~8のいずれか一項に記載の医薬組成物を部位に局所投与することから成る、該部位における骨形成促進方法。

【請求項12】歯槽骨部に局所投与することから成る、請求項11記載の方法。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • TOHOKU UNIVERSITY
  • SHOWA UNIVERSITY
  • Inventor
  • SHINODA, Hisashi
  • IGARASHI, Kaoru
  • MURAKAMI, shinobu
  • SUZUKI, Keiko
IPC(International Patent Classification)
Specified countries AE(UTILITY MODEL),AG,AL(UTILITY MODEL),AM(PROVISIONAL PATENT)(UTILITY MODEL),AO(UTILITY MODEL),AT(UTILITY MODEL),AU,AZ(UTILITY MODEL),BA,BB,BG(UTILITY MODEL),BH(UTILITY MODEL),BR(UTILITY MODEL),BW(UTILITY MODEL),BY(UTILITY MODEL),BZ(UTILITY MODEL),CA,CH,CL(UTILITY MODEL),CN(UTILITY MODEL),CO(UTILITY MODEL),CR(UTILITY MODEL),CU(INVENTOR'S CERTIFICATE),CZ(UTILITY MODEL),DE(UTILITY MODEL),DK(UTILITY MODEL),DM,DO(UTILITY MODEL),DZ,EC(UTILITY MODEL),EE(UTILITY MODEL),EG(UTILITY MODEL),ES(UTILITY MODEL),FI(UTILITY MODEL),GB,GD,GE(UTILITY MODEL),GH(UTILITY CERTIFICATE),GM,GT(UTILITY MODEL),HN,HR(CONSENSUAL PATENT),HU(UTILITY MODEL),ID,IL,IN,IS,JP(UTILITY MODEL),KE(UTILITY MODEL),KG(UTILITY MODEL),KM,KN,KP(INVENTOR'S CERTIFICATE)(UTILITY MODEL),KR(UTILITY MODEL),KZ(PROVISIONAL PATENT)(UTILITY MODEL),LA,LC,LK,LR,LS(UTILITY MODEL),LT,LU,LY,MA,MD(UTILITY MODEL),ME,MG,MK,MN,MW,MX(UTILITY MODEL),MY(UTILITY-INNOVATION),MZ(UTILITY MODEL),NA,NG,NI(UTILITY MODEL),NO,NZ,OM(UTILITY MODEL),PE(UTILITY MODEL),PG,PH(UTILITY MODEL),PL(UTILITY MODEL),PT(UTILITY MODEL),RO,RS(PETTY PATENT),RU(UTILITY MODEL),SC,SD,SE,SG,SK(UTILITY MODEL),SL(UTILITY MODEL),SM,ST,SV(UTILITY MODEL),SY,TJ(UTILITY MODEL),TM(PROVISIONAL PATENT),TN,TR(UTILITY MODEL),TT(UTILITY CERTIFICATE),TZ,UA(UTILITY MODEL),UG(UTILITY CERTIFICATE),US,UZ(UTILITY MODEL),VC(UTILITY CERTIFICATE),VN(PATENT FOR UTILITY SOLUTION),ZA,ZM,ZW,EP(AT,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LT,LU,LV,MC,MK,MT,NL,NO,PL,PT,RO,SE,SI,SK,SM,TR),OA(BF(UTILITY MODEL),BJ(UTILITY MODEL),CF(UTILITY MODEL),CG(UTILITY MODEL),CI(UTILITY MODEL),CM(UTILITY MODEL),GA(UTILITY MODEL),GN(UTILITY MODEL),GQ(UTILITY MODEL),GW(UTILITY MODEL),ML(UTILITY MODEL),MR(UTILITY MODEL),NE(UTILITY MODEL),SN(UTILITY MODEL),TD(UTILITY MODEL),TG(UTILITY MODEL)),AP(BW(UTILITY MODEL),GH(UTILITY MODEL),GM(UTILITY MODEL),KE(UTILITY MODEL),LS(UTILITY MODEL),MW(UTILITY MODEL),MZ(UTILITY MODEL),NA(UTILITY MODEL),SD(UTILITY MODEL),SL(UTILITY MODEL),SZ(UTILITY MODEL),TZ(UTILITY MODEL),UG(UTILITY MODEL),ZM(UTILITY MODEL),ZW(UTILITY MODEL)),EA(AM,AZ,BY,KG,KZ,MD,RU,TJ,TM)
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