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HUMAN HEPATIC STEM CELL, METHOD FOR PREPARATION OF THE SAME, METHOD FOR INDUCTION OF DIFFERENTIATION OF THE SAME, AND METHOD FOR UTILIZATION OF THE SAME

外国特許コード F110003040
整理番号 S2008-0611-C0
掲載日 2011年5月20日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2009JP058932
国際公開番号 WO 2009139419
国際出願日 平成21年5月13日(2009.5.13)
国際公開日 平成21年11月19日(2009.11.19)
優先権データ
  • 特願2008-127755 (2008.5.14) JP
発明の名称 (英語) HUMAN HEPATIC STEM CELL, METHOD FOR PREPARATION OF THE SAME, METHOD FOR INDUCTION OF DIFFERENTIATION OF THE SAME, AND METHOD FOR UTILIZATION OF THE SAME
発明の概要(英語) Disclosed is a human hepatic stem cell. The human hepatic stem cell is isolated based on the presence or absence of the expression of at least one marker selected from the group consisting of CD318, CD90, CD66 and CD13. Further disclosed are: a method for preparing the human hepatic stem cell; a method for inducing the differentiation of the human hepatic stem cell; a method for utilizing the human hepatic stem cell; and others.
従来技術、競合技術の概要(英語) BACKGROUND ART
Conventional, separation of stem cells, have been used as the centrifugation method (non-patent document 1). However, in this method can easily be contaminated by cells other than stem cells, that can efficiently separate was difficult. Therefore, only the stem cells with higher efficiency and a method of separating method has been developed. Recent reports show that, in each organ stem cell specific cell surface antigen using a monoclonal antibody to the separation method is most suitable for the considered, the separation of hematopoietic stem cells are popular. Liver stem cells for specific cell surface antigen, that has not been identified so far, by a group of the inventors of the present invention, the expression of the 5-6 type of cell surface antigen as an index, liver from mouse liver stem cells using a method has been reported (non-patent document 2 and 3). Miyajima et al., mouse embryonic and adult liver stem cells in the liver, dlk (delta-like) and the specific high expression Itm2A(Integral membrane protein 2A) and genes, these protein, expression of mRNA as an index, detection or separation of liver stem cells can be performed and reported (Patent Document 1). Further, based on their expression of specific sugar chain can be separated rat liver stem cells also have been reported (patent document 2).
In addition, ectodermal stem cells in lymphoid tissue have been considered to marker protein is p75NTR, and synthesized in all tissues has been reported that, in combination with it by a known marker protein, separation of the pluripotent stem cells, identified, induction of cell differentiation are improved efficiencies (Patent Document 3).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • Public University Corporation Yokohama City University
  • 発明者(英語)
  • TANIGUCHI, Hideki
  • ZHENG, Yun-Wen
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PG PH PL PT RO RS RU SC SD SE SG SK SL SM ST SV SY TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ MD RU TJ TM
EPO: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
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