Top > Search of International Patents > Removal promoters and inhibitor for apoptosis cells in vivo

Removal promoters and inhibitor for apoptosis cells in vivo achieved

Foreign code F110003165
File No. A131-11US3
Posted date Jun 17, 2011
Country United States of America
Application number 45742309
Gazette No. 20100136100
Gazette No. 8603455
Date of filing Jun 10, 2009
Gazette Date Jun 3, 2010
Gazette Date Dec 10, 2013
International application number JP2002012053
International publication number WO2003043649
Date of international filing Nov 19, 2002
Date of international publication May 30, 2003
Priority data
  • P2001-354282 (Nov 20, 2001) JP
  • 2002WO-JP12053 (Nov 19, 2002) WO
  • 2004US-10496087 (Nov 9, 2004) US
  • 2007US-11984033 (Nov 13, 2007) US
Title Removal promoters and inhibitor for apoptosis cells in vivo achieved
Abstract (US8603455)
The present invention is to provide a removal promoter for apoptotic cells which is capable of immediately removing apoptotic cells in vivo by macrophages, or a removal inhibitor which inhibits the removal of apoptotic cells in vivo by macrophages.
A removal promoter for apoptotic cells in vivo containing the milk fat globule-EGF factor 8-L (MFG-E8-L), MFG-E8-L mutant having removal promotion action for apoptotic cells in vivo by macrophages, or preferably a recombinant human or mouse MFG-E8-L, or a recombinant human or mouse MFG-E8-L mutant as an active ingredient is prepared.
Such removal promoters specifically bind to apoptotic cells and promote the phagocytosis of apoptotic cells by macrophages by recognizing aminophospholipids such as phosphatidylserine exposed on apoptotic cell surface.
On the other hand, a point mutation (D89E) MFG-E8-L mutant is used as a removal inhibitor.
Scope of claims [claim1]
1. A method for promoting phagocytosis of apoptotic cells by macrophages, comprising contacting said apoptotic cells and said macrophages with a composition comprising isolated human milk fat globule-EGF factor 8-L (MFG-E8-L).
[claim2]
2. The method according to claim 1, wherein the human MFG-E8-L is a translation product in human cells.
[claim3]
3. The method according to claim 1, wherein the human MFG-E8-L is enveloped or embedded in liposome.
  • Inventor, and Inventor/Applicant
  • NAGATA SHIGEKAZU
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
IPC(International Patent Classification)
Reference ( R and D project ) CREST Structure and Function of Genomes AREA
Please contact us by E-mail or facsimile if you have any interests on this patent.

PAGE TOP

close
close
close
close
close
close