Antibody and inhibitor, and transfection method or kit using them
|Posted date||Jun 22, 2011|
|Country||United States of America|
|Date of filing||Dec 12, 2008|
|Gazette Date||Apr 23, 2009|
|Gazette Date||Dec 13, 2011|
|International application number||JP2003001673|
|International publication number||WO2003106499|
|Date of international filing||Feb 17, 2003|
|Date of international publication||Dec 24, 2003|
|Title||Antibody and inhibitor, and transfection method or kit using them|
The present invention provides a monoclonal antibody which specifically binds to human Toll-like receptor 3 and inhibits production of type 1 interferon.
It also provides an inhibitor which (a) suppresses a double-stranded RNA-mediated immune response in a cell which expresses Toll-like receptor 3 that recognizes the double-stranded RNA and produces type I interferon, and (b) includes an antibody, which binds to the Toll-like receptor 3 and inhibits production of the type I interferon.
Particularly, the monoclonal antibody is against human Toll-like receptor 3.
Further, a transfection method and kit are provided.
Production of type I interferon can be controlled by using an antibody which specifically binds to Toll-like receptor 3 that recognizes a double-stranded RNA and produces type I interferon.
|Scope of claims||
1. An isolated antibody which binds to human Toll-like receptor 3 and does not bind to human Toll-like receptor 2, wherein said antibody is produced by hybridoma TLR3.7 (FERM BP-10597).
|IPC(International Patent Classification)||
|Reference ( R and D project )||CREST Protein Structure and Functional Mechanisms -Toward Creation of Innovative Medicines, Diagnosis, and Material Production Based on Functional Mechanisms of Proteins- AREA|
Contact Information for " Antibody and inhibitor, and transfection method or kit using them "
- Japan Science and Technology Agency Department of Intellectual Property Management
- URL: http://www.jst.go.jp/chizai/
- Address: 5-3, Yonbancho, Chiyoda-ku, Tokyo, Japan , 102-8666
- Fax: 81-3-5214-8476