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Antibody and inhibitor, and transfection method or kit using them achieved

Foreign code F110003336
File No. A211-01US2
Posted date Jun 22, 2011
Country United States of America
Application number 31455608
Gazette No. 20090105460
Gazette No. 8076460
Date of filing Dec 12, 2008
Gazette Date Apr 23, 2009
Gazette Date Dec 13, 2011
International application number JP2003001673
International publication number WO2003106499
Date of international filing Feb 17, 2003
Date of international publication Dec 24, 2003
Priority data
  • P2002-171952 (Jun 12, 2002) JP
  • 2003WO-JP01673 (Feb 17, 2003) WO
  • 2004US-10512873 (Oct 29, 2004) US
Title Antibody and inhibitor, and transfection method or kit using them achieved
Abstract (US8076460)
The present invention provides a monoclonal antibody which specifically binds to human Toll-like receptor 3 and inhibits production of type 1 interferon.
It also provides an inhibitor which (a) suppresses a double-stranded RNA-mediated immune response in a cell which expresses Toll-like receptor 3 that recognizes the double-stranded RNA and produces type I interferon, and (b) includes an antibody, which binds to the Toll-like receptor 3 and inhibits production of the type I interferon.
Particularly, the monoclonal antibody is against human Toll-like receptor 3.
Further, a transfection method and kit are provided.
Production of type I interferon can be controlled by using an antibody which specifically binds to Toll-like receptor 3 that recognizes a double-stranded RNA and produces type I interferon.
Scope of claims [claim1]
1. An isolated antibody which binds to human Toll-like receptor 3 and does not bind to human Toll-like receptor 2, wherein said antibody is produced by hybridoma TLR3.7 (FERM BP-10597).
  • Inventor, and Inventor/Applicant
  • MATSUMOTO MISAKO
  • SEYA TSUKASA
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
IPC(International Patent Classification)
Reference ( R and D project ) CREST Protein Structure and Functional Mechanisms -Toward Creation of Innovative Medicines, Diagnosis, and Material Production Based on Functional Mechanisms of Proteins- AREA
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