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Random copolymers of oxazoline

外国特許コード F110003388
整理番号 A252-32WO
掲載日 2011年6月23日
出願国 アメリカ合衆国
出願番号 99128206
公報番号 20090156782
公報番号 7732561
出願日 平成18年8月30日(2006.8.30)
公報発行日 平成21年6月18日(2009.6.18)
公報発行日 平成22年6月8日(2010.6.8)
国際出願番号 JP2006317587
国際公開番号 WO2007026932
国際出願日 平成18年8月30日(2006.8.30)
国際公開日 平成19年3月8日(2007.3.8)
優先権データ
  • 特願2005-253977 (2005.9.1) JP
  • 2006WO-JP317587 (2006.8.30) WO
発明の名称 (英語) Random copolymers of oxazoline
発明の概要(英語) (US7732561)
The invention provides approximately monodispersible random copolymers obtained from monomeric mixtures of 2-ethyl-2-oxazoline with 2-isopropyl-2-oxazoline, production method thereof and 2-isopropyl-2-oxazoline homopolymer obtained by using special initiator.
Such polymers exhibit temperature-responsiveness in an aqueous solution within a broad temperature range, and are useful materials in the technical fields of surface chemistry and biomaterials.
特許請求の範囲(英語) [claim1]
1. A production method of a homopolymer represented by the following formula:
wherein R3 stands for hydrogen or C1-5 alkyl, m stands for an integer of 1-20, and n stands for an integer of 5-10,000,
which comprises a step of ring-opening polymerizing with 2-isopropyl-2-oxazoline in an inert solvent at 30 deg. C.-50 deg. C. in the presence of a cationic polymerization initiator, a step of reacting the resultant homopolymer with a nucleophilic agent, and, where necessary, a step of isolating the formed homopolymer.
[claim2]
2. The production method according to claim 1, in which the cationic polymerization initiator is a substituted or unsubstituted, straight chain or branched C1-20 alkyl tosylate.
[claim3]
3. The production method according to claim 2, in which the substituent on the substituted straight chain or branched C1-20 alkyl is represented by a formula,
or a formula,
R3C≡C -- ,
wherein R1 and R2 either stand for C1-10 alkoxy, aryloxy or aryl-C1-3 alkyloxy, independently of each other, or R1 and R2 together stand for optionally C1-5 alkyl-substituted ethylenedioxy ( -- O -- CH(R') -- CH2 -- O -- , R' being hydrogen or C1-5 alkyl) or oxy (.dbd.0) group, and
R3 stands for hydrogen or C1-5 alkyl.
[claim4]
4. A homopolymer represented by the following formula
in the formula, R3 stands for hydrogen or C1-5 alkyl, m stands for an integer of 1-20, and n stands for an integer of 5-10,000.
  • 発明者/出願人(英語)
  • KATAOKA KAZUNORI
  • YAMASAKI YUICHI
  • PARK JOON-SIK
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
参考情報 (研究プロジェクト等) CREST Creation of Bio-Devices and Bio-Systems with Chemical and Biological Molecules for Medical Use AREA
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