Random copolymers of oxazoline
|Posted date||Jun 23, 2011|
|Country||United States of America|
|Date of filing||Aug 30, 2006|
|Gazette Date||Jun 18, 2009|
|Gazette Date||Jun 8, 2010|
|International application number||JP2006317587|
|International publication number||WO2007026932|
|Date of international filing||Aug 30, 2006|
|Date of international publication||Mar 8, 2007|
|Title||Random copolymers of oxazoline|
The invention provides approximately monodispersible random copolymers obtained from monomeric mixtures of 2-ethyl-2-oxazoline with 2-isopropyl-2-oxazoline, production method thereof and 2-isopropyl-2-oxazoline homopolymer obtained by using special initiator.
Such polymers exhibit temperature-responsiveness in an aqueous solution within a broad temperature range, and are useful materials in the technical fields of surface chemistry and biomaterials.
|Scope of claims||
1. A production method of a homopolymer represented by the following formula:
wherein R3 stands for hydrogen or C1-5 alkyl, m stands for an integer of 1-20, and n stands for an integer of 5-10,000,
which comprises a step of ring-opening polymerizing with 2-isopropyl-2-oxazoline in an inert solvent at 30 deg. C.-50 deg. C. in the presence of a cationic polymerization initiator, a step of reacting the resultant homopolymer with a nucleophilic agent, and, where necessary, a step of isolating the formed homopolymer.
2. The production method according to claim 1, in which the cationic polymerization initiator is a substituted or unsubstituted, straight chain or branched C1-20 alkyl tosylate.
3. The production method according to claim 2, in which the substituent on the substituted straight chain or branched C1-20 alkyl is represented by a formula,
or a formula,
R3C≡C -- ,
wherein R1 and R2 either stand for C1-10 alkoxy, aryloxy or aryl-C1-3 alkyloxy, independently of each other, or R1 and R2 together stand for optionally C1-5 alkyl-substituted ethylenedioxy ( -- O -- CH(R') -- CH2 -- O -- , R' being hydrogen or C1-5 alkyl) or oxy (.dbd.0) group, and
R3 stands for hydrogen or C1-5 alkyl.
4. A homopolymer represented by the following formula
in the formula, R3 stands for hydrogen or C1-5 alkyl, m stands for an integer of 1-20, and n stands for an integer of 5-10,000.
|IPC(International Patent Classification)|
|Reference ( R and D project )||CREST Creation of Bio-Devices and Bio-Systems with Chemical and Biological Molecules for Medical Use AREA|
Contact Information for " Random copolymers of oxazoline "
- Japan Science and Technology Agency Department of Intellectual Property Management
- URL: http://www.jst.go.jp/chizai/
- Address: 5-3, Yonbancho, Chiyoda-ku, Tokyo, Japan , 102-8666
- Fax: 81-3-5214-8476