p CHANNEL FILED EFFECT TRANSISTOR AND SENSOR USING THE SAME
|Posted date||Jun 27, 2011|
|Date of filing||Mar 25, 2004|
|Gazette Date||Dec 28, 2005|
|Gazette Date||Mar 15, 2017|
|International application number||JP2004004196|
|International publication number||WO2004086025|
|Date of international filing||Mar 25, 2004|
|Date of international publication||Oct 7, 2004|
|Title||p CHANNEL FILED EFFECT TRANSISTOR AND SENSOR USING THE SAME|
A p channel field effect transistor in which the sensitivity of an enzyme can be enhanced by immobilizing the enzyme directly on an FET channel surface (diamond surface), as well as a sensor including the same, is provided.
A diamond surface (22) having mixed hydrogen terminals, oxygen terminals, and amino terminals is treated under the action of glutaraldehyde OHC(CH2)3CHO (30), so that the glutaraldehyde (30) is immobilized on the diamond surface (22) having mixed hydrogen terminals, oxygen terminals, and amino terminals.
Subsequently, urease (29) is further applied thereto, so that the amino group (31) of the urease (29) is bonded to the glutaraldehyde (30).
That is, the urease (29) can be immobilized on the diamond surface (22) having mixed hydrogen terminals, oxygen terminals, and amino terminals.
When the urea concentration is increased from 10<-6> M to 10<-2> M, the threshold voltage shifts by about 0.1 V in the positive direction, and the sensitivity to urea concentration of 30 mV/decade is exhibited. <IMAGE>
|Scope of claims||
1. A p channel field effect transistor in which a liquid electrolyte is used as a gate, and a polycrystalline or monocrystalline diamond surface having mixed hydrogen terminals, oxygen terminals, and amino terminals serves as a channel.
2. A sensor characterized by including the p channel field effect transistor according to Claim 1 and exhibiting a pH sensitivity through the use of a shift of threshold voltage in the positive direction on the surface having mixed amino terminals and oxygen terminals in response to an increase in pH of the liquid electrolyte.
3. The sensor according to Claim 2, characterized in that the increase in pH is 2 to 12.
4. The sensor according to Claim 2 or Claim 3, characterized in that urease is immobilized to the amino terminal on the surface with glutaraldehyde (divalent aldehyde) therebetween, the threshold voltage shifts in the positive direction in response to an increase in urea concentration and, thereby, the sensitivity to urea is exhibited.
5. The sensor according to Claim 4, characterized in that the increase in urea concentration is 10**-6 M to 10**-2 M.
|IPC(International Patent Classification)|
|Reference ( R and D project )||CREST Function Evolution of Materials and Devices based on Electron/Photon Related Phenomena AREA|
Contact Information for " p CHANNEL FILED EFFECT TRANSISTOR AND SENSOR USING THE SAME "
- Japan Science and Technology Agency Department of Intellectual Property Management
- URL: http://www.jst.go.jp/chizai/
- Address: 5-3, Yonbancho, Chiyoda-ku, Tokyo, Japan , 102-8666
- Fax: 81-3-5214-8476