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Method of examining colon cancer and colon adenoma

外国特許コード F110003464
整理番号 A261-02WO
掲載日 2011年6月27日
出願国 アメリカ合衆国
出願番号 56854404
公報番号 20070196874
公報番号 07601348
出願日 平成18年9月22日(2006.9.22)
公報発行日 平成19年8月23日(2007.8.23)
公報発行日 平成21年10月13日(2009.10.13)
国際出願番号 PCT/JP2004/009805
国際公開番号 WO2005/019827
国際出願日 平成16年7月9日(2004.7.9)
国際公開日 平成17年3月3日(2005.3.3)
  • 特願2003-296216 (2003.8.20) JP
発明の名称 (英語) Method of examining colon cancer and colon adenoma
発明の概要(英語) The present invention provides a method for examining colorectal cancer and colorectal adenoma, which enables to detect colorectal cancer patients and patients at high risk of colorectal cancer at a high probability and is useful for diagnosis of colorectal cancer and colorectal adenoma, and provides the examination reagents thereof. The present inventors discovered that there are significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, among non-cancer colorectal tissues, colorectal cancer tissues and colorectal adenoma tissues. Furthermore the inventors applied the discovery to diagnosis and found that colorectal cancers and adenomas are detected specifically by assaying a definite range of GlcNAc-6-sulfated sugar residues in tissues from patients or feces samples. MECA-79 antibody (Pharmingen, catalog No. 09961D, Distributor: Becton Dickinson), reacting with GlcNAc-6-sulfated sugar residues, which are produced specifically by the enzyme present in colorectal cancer and colorectal adenoma tissues could be used for the examination of colorectal cancers and colorectal adenomas.
  • 発明者/出願人(英語)
  • Kannagi, Reiji; Nagoya [JP]
  • Izawa, Mineko; Seto [JP]
  • Muramatsu, Takashi; Nagoya [JP]
  • Uchimura, Kenji; San Francisco CA [US]
  • Hosokawa, Hideaki; Suita [JP]
  • Japan Science & Technology Agency, Saitama [JP]
  • Local Government of Aichi Prefecture, Aichi-ken [JP]
  • Wako Pure Chemical Industries, Ltd., Osaka [JP]
  • 424/130.1
  • 435/7.23
参考情報 (研究プロジェクト等) CREST Clarification of the Biological Functions of Sugar Chains and the Use of this Knowledge in Applied Technologies AREA