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Method for detection of disease having insulin-resistant conditions

外国特許コード F110003466
整理番号 A261-07WO
掲載日 2011年6月27日
出願国 アメリカ合衆国
出願番号 30199707
公報番号 20100273192
公報番号 8465930
出願日 平成19年5月29日(2007.5.29)
公報発行日 平成22年10月28日(2010.10.28)
公報発行日 平成25年6月18日(2013.6.18)
国際出願番号 JP2007061246
国際公開番号 WO2007139224
国際出願日 平成19年5月29日(2007.5.29)
国際公開日 平成19年12月6日(2007.12.6)
優先権データ
  • 特願2006-149328 (2006.5.30) JP
  • 2007WO-JP61246 (2007.5.29) WO
発明の名称 (英語) Method for detection of disease having insulin-resistant conditions
発明の概要(英語) (US8465930)
Disclosed is a simple method for detecting a pathological condition of an insulin-resistant disease, particularly type-2 diabetes.
The method comprises quantifying the ganglioside GM3 in a blood sample separated from a living body.
More specifically, the method comprises the following steps (a) to (c): (a) separating a plasma or serum from the blood collected from a human; (b) quantifying the ganglioside GM3 in the plasma or serum; and (c) comparing the quantified ganglioside GM3 level to the mean ganglioside GM3 level determined in blood samples from healthy volunteers.
特許請求の範囲(英語) [claim1]
1. A method for detection of a disease selected from the group consisting of type 2 diabetes and type 2 diabetes combined with hyperlipidemia, wherein said type 2 diabetes group having a Body Mass Index level greater than 30, which comprises: separating plasma or serum from human blood collected;
quantifying ganglioside GM3 in the plasma or serum separated; and,
comparing the GM3 level quantified to a mean ganglioside GM3 level in blood samples derived from healthy volunteers, thereby detecting the disease.
[claim2]
2. The method for detection according to claim 1, wherein said quantification of ganglioside GM3 is performed by high performance liquid chromatography (HPLC), high performance thin layer chromatography (HPTLC), high performance liquid chromatography-mass spectrometry (LC-MS), gas chromatography-mass spectrometry (GC-MS) or enzyme linked immunosorbent assay (ELISA) using an anti-GM3 antibody.
[claim3]
3. The method according to claim 1, wherein said disease is type 2 diabetes.
[claim4]
4. A method for predicting a risk of developing a disease selected from the group consisting of type 2 diabetes and type 2 diabetes combined with hyperlipidemia, wherein said type 2 diabetes group having a Body Mass Index level greater than 30, which comprises: separating plasma or serum from human blood collected;
quantifying ganglioside GM3 in the plasma or serum separated;
comparing the GM3 level quantified to a normal ganglioside GM3 level in blood samples from healthy volunteers; and
monitoring changes in the ganglioside GM3 level, thereby predicting the risk.
[claim5]
5. The method according to claim 4, wherein said quantification of ganglioside GM3 is performed by high performance liquid chromatography (HPLC), high performance thin layer chromatography (HPTLC), high performance liquid chromatography-mass spectrometry (LC-MS), gas chromatography-mass spectrometry (GC-MS) or enzyme linked immunosorbent assay (ELISA) using an anti-GM3 antibody.
[claim6]
6. The method according to claim 4, wherein a blood sample is regularly collected from the human and changes in the ganglioside GM3 level in the blood sample collected are monitored.
[claim7]
7. The method according to claim 4, wherein said disease is type 2 diabetes.
[claim8]
8. The method of claim 1, wherein the disease is type 2 diabetes combined with hyperlipidemia.
[claim9]
9. The method of claim 1, wherein the disease is a diabetic group having a Body Mass Index level greater than 30.
[claim10]
10. The method of claim 4, wherein the disease is type 2 diabetes combined with hyperlipidemia.
[claim11]
11. The method of claim 4, wherein the disease is a diabetic group having a Body Mass Index level greater than 30.
  • 発明者/出願人(英語)
  • INOKUCHI JINICHI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
参考情報 (研究プロジェクト等) CREST Clarification of the Biological Functions of Sugar Chains and the Use of this Knowledge in Applied Technologies AREA
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