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Method for preparing porous composite material

Foreign code F110003480
File No. A122-29EP
Posted date Jun 28, 2011
Country EPO
Application number 02722917
Gazette No. 1500405
Gazette No. 1500405
Date of filing May 1, 2002
Gazette Date Jan 26, 2005
Gazette Date Mar 5, 2014
International application number JP2002004355
International publication number WO2003092759
Date of international filing May 1, 2002
Date of international publication Nov 13, 2003
Priority data
  • 2002JP004355 (May 1, 2002) WO
Title Method for preparing porous composite material
Abstract This invention relates to a process for producing porous and composite materials comprising steps of: freezing a complex containing at least one calcium salt selected from calcium carbonate, calcium phosphate, and hydroxyapatite and collagen, at least a part of which is gelatinized; and then lyophilizing the resultant.
The porous and composite materials obtained by the method of the present invention have large pore diameters, high porosities, and adequate mechanical strengths and biodegradability.
Thus, they are suitable for implants such as bone fillers, drug carriers for sustained-release, and the like.
Scope of claims [claim1]
1. A process for producing porous and composite materials comprising steps of: heating a complex containing at least one calcium salt selected from calcium carbonate, calcium phosphate, and hydroxyapatite and collagen for a reaction time between 60 to 120 min and at a reaction temperature between 35 deg.C and 45 deg.C with adding acid or for a reaction time between 60 to 120 min and at a reaction temperature between 40 deg.C and 50 deg.C without adding acid thereby gelatinizing at least a part of the collagen, cooling the heated complex until the complex gels, to provide a gelled complex; freezing the gelled complex; and then lyophilizing the resultant to produce porous and composite materials.
[claim2]
2. The process for producing porous and composite materials according to claim 1, wherein said process comprises a step of introducing surface crosslinking into at least 1% of the reactive groups of collagens on said porous and composite materials produced, wherein the surface crosslinking is introduced between collagens that are present on the surface of the porous and composite materials.
[claim3]
3. The process according to claim 2, wherein the step of introducing surface crosslinking is carried out by immersing the porous and composite materials in a solution containing 0,001% to 1% of glutaraldehyde as a crosslinking agent for 60 minutes to 5 hours.
[claim4]
4. The process according to any one of claims 1 to 3 comprising a step of adding a crosslinking agent to gelatinized collagen to introduce internal crosslinking between collagens, wherein the internal crosslinking is introduced between collagens that are present in the complex.
[claim5]
5. The process according to any one of claims 1 to 4, wherein the calcium salt is hydroxyapatite.
[claim6]
6. The process according to any one of claims 2 to 5, wherein internal and/or surface crosslinking between collagens is introduced using glutaraldehyde as a crosslinking agent.
[claim7]
7. The process according to any one of claims 2 to 6, wherein surface crosslinking between collagens is introduced by immersing the porous and composite materials in a solution containing a crosslinking agent comprising ethanol as a solvent.
[claim8]
8. The process according to any one of claims 1 to 7, wherein the resulting porous and composite materials have porosities of 80% or higher.
[claim9]
9. The process according to any one of claims 1 to 8 using a complex comprising the c-axis of hydroxyapatite being oriented along collagen fibers.
  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • NATIONAL INSTITUTE FOR MATERIALS SCIENCE
  • NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
  • Inventor
  • SOTOME SHINICHI
  • UEMURA TOSHIMASA
  • TANAKA JUNZO
  • KIKUCHI MASANORI
  • SHINOMIYA KENICHI
  • ITOH SOICHIRO
  • TATEISHI TETSUYA
IPC(International Patent Classification)
Reference ( R and D project ) CREST Creation and Functions of New Molecules and Molecular Assemblies AREA
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