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Method and a system for predicting protein functional site, a method for improving protein function, and a function-modified protein

Foreign code F110003599
File No. E04401US3
Posted date Jun 30, 2011
Country United States of America
Application number 80644807
Gazette No. 20080262201
Gazette No. 7820423
Date of filing May 31, 2007
Gazette Date Oct 23, 2008
Gazette Date Oct 26, 2010
International application number JP1998000430
International publication number WO1998033900
Date of international filing Feb 2, 1998
Date of international publication Aug 6, 1998
Priority data
  • P1997-019248 (Jan 31, 1997) JP
  • P1997-019249 (Jan 31, 1997) JP
  • P1997-332100 (Dec 2, 1997) JP
  • P1998-018699 (Jan 30, 1998) JP
  • 1998WO-JP00430 (Feb 2, 1998) WO
  • 1999US-09355486 (Sep 20, 1999) US
  • 2000US-09697138 (Oct 27, 2000) US
  • 2003US-10345205 (Jan 16, 2003) US
Title Method and a system for predicting protein functional site, a method for improving protein function, and a function-modified protein
Abstract (US7820423)
The present application provides a method for predicting the functional site of a protein using data of the entire proteins of an organism of which genome data or cDNA data is known.
More specifically, the present application provides a method for predicting a protein functional site, comprising the steps of calculating the frequency of occurrence of an oligopeptide in the entire proteins, calculating the value of each amino-acid residue contributing to the frequency of occurrence as the representative value of the function, and predicting the protein functional site by using the representative value of function as an indicator.
The present also provides a system for predicting a functional site for automatically performing said methods.
Additionally, the present application provides a method for preparing a function-modified protein comprising subjecting the amino-acid residues composing the functional site identified by the method described above to artificial mutation, and a novel thermophilic DNA polymerase prepared by the method.
Scope of claims [claim1]
1. A thermophilic DNA polymerase consisting of the amino acid sequence of SEQ ID NO: 6.
  • Inventor, and Inventor/Applicant
  • DOI HIROFUMI
  • HIRAKI HIDEAKI
  • KANAI AKIO
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
IPC(International Patent Classification)
Reference ( R and D project ) ERATO DOI Bioasymmetry AREA
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