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Method of amidocarbonylation reaction

外国特許コード F110003806
整理番号 E07604WO
掲載日 2011年7月5日
出願国 アメリカ合衆国
出願番号 59213805
公報番号 20070197765
公報番号 7732638
出願日 平成17年3月10日(2005.3.10)
公報発行日 平成19年8月23日(2007.8.23)
公報発行日 平成22年6月8日(2010.6.8)
国際出願番号 JP2005004715
国際公開番号 WO2005085180
国際出願日 平成17年3月10日(2005.3.10)
国際公開日 平成17年9月15日(2005.9.15)
優先権データ
  • 特願2004-068206 (2004.3.10) JP
  • 2005WO-JP04715 (2005.3.10) WO
発明の名称 (英語) Method of amidocarbonylation reaction
発明の概要(英語) (US7732638)
A novel method of an amidocarbonylation reaction among an aldehyde compound, an amide compound, and carbon monoxide, which comprises using a palladium-supporting crosslinked-polymer composition containing palladium clusters having a major-axis length of 20 nm or shorter to conduct the amidocarbonylation reaction.
Thus, an N-acyl-α-amino acid can be more efficiently and selectively synthesized in a dean reaction system.
Also provided is a catalyst for use in the method.
特許請求の範囲(英語) [claim1]
1. In an amidocarbonylation reaction which comprises reacting an aldehyde compound represented by the formula

where R1 is a hydrogen atom or a hydrocarbon group that may be substituted, with carbon monoxide and an amide compound represented by the formula

where R2 is a hydrocarbon group that may be substituted, to produce an amino acid compound represented by the formula

where R1 and R2 are the same as above, the improvement wherein the reaction is conducted in the presence of a palladium-supported crosslinked polymer composition containing a palladium cluster having a major axis of 20 nm or less; wherein the said palladium-supported crosslinked polymer composition is one obtained by immobilizing palladium to a copolymer of monomers containing styrene compounds represented by formulas (1), (2) and (3) below

Where RX and RY are hydrogen atom or a substitution group of formula (1a), at least one of RX and RY being a hydrogen atom,

n is an integer of 0 to 6, m is an integer of 1 to 6, l is an integer of 0 to 10, Ra is a hydrogen atom or a hydrocarbon group that may be substituted, Rb is a hydrocarbon group that may be substituted, and Ra and Rb may combine with each other to form a lactam ring.
[claim2]
2. The amidocarbonylation reaction according to claim 1, wherein the palladium has zero valence.
[claim3]
3. The amidocarbonylation reaction according to claim 1, wherein the copolymer is represented by the formula below

where v is 0-90, w is 3-80, x is 0-20, y is 3-20 and z is 0-20, with the proviso that x and z are not both zero.
[claim4]
4. The amidocarbonylation reaction according to claim 2, wherein the copolymer is represented by the formula below

where v is 0-90, w is 3-80, x is 0-20, y is 3-20 and z is 0-20, with the proviso that z are not both zero.
  • 発明者/出願人(英語)
  • KOBAYASHI SHU
  • AKIYAMA RYO
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
参考情報 (研究プロジェクト等) ERATO KOBAYASHI Highly Functionalized Reaction Environments AREA
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