Method for manufacturing an optically active hydroxymethylated compound and a catalyst therefore
| 外国特許コード | F110003812 |
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| 整理番号 | E07612WO |
| 掲載日 | 2011年7月5日 |
| 出願国 | アメリカ合衆国 |
| 出願番号 | 79552506 |
| 公報番号 | 20080139835 |
| 公報番号 | 7541307 |
| 出願日 | 平成18年1月27日(2006.1.27) |
| 公報発行日 | 平成20年6月12日(2008.6.12) |
| 公報発行日 | 平成21年6月2日(2009.6.2) |
| 国際出願番号 | JP2006301293 |
| 国際公開番号 | WO2006080425 |
| 国際出願日 | 平成18年1月27日(2006.1.27) |
| 国際公開日 | 平成18年8月3日(2006.8.3) |
| 優先権データ |
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| 発明の名称 （英語） | Method for manufacturing an optically active hydroxymethylated compound and a catalyst therefore |
| 発明の概要（英語） |
(US7541307) A silicon enolate represented by the following formula (Formula 1) (in the formula, R5 to R7 represent hydrogen atoms, aliphatic hydrocarbon groups, monocyclic or polycyclic alicyclic hydrocarbon groups, monocyclic or polycyclic aromatic or aromatic-aliphatic hydrocarbon groups or heterocyclic groups, R5 and R7 are different, R6 is not a hydrogen atom, each R8 may be identical or different and represents a methyl group, ethyl group or isopropyl group) and formaldehyde are allowed to react in an aqueous solution or a mixed solvent of water and an organic solvent in the presence of a catalyst obtained by mixing a ligand comprising a chiral bipyridine compound or its antipode and Bi(OTf)3. |
| 特許請求の範囲（英語） |
[claim1] 1. A method for manufacturing an optically active hydroxymethylated compound that allows a silicon enolate represented by the following formula (Formula 1) (in the formula, R5 to R7 represent hydrogen atoms, aliphatic hydrocarbon groups, monocyclic or polycyclic alicyclic hydrocarbon groups, monocyclic or polycyclic aromatic or aromatic-aliphatic hydrocarbon groups or heterocyclic groups, R5 and R7 are different, R6 is not a hydrogen atom, each R8 may be identical or different and represents a methyl group, ethyl group or isopropyl group) and formaldehyde to react in an aqueous solution or in a mixed solvent of water and an organic solvent or in a mixed solvent of water and organic solvents in the presence of a catalyst obtained by blending a ligand comprising a chiral bipyridine compound or its antipode and a Lewis acid represented by BiY3 (in the formula, Y represents a halogen atom, OAc, OCOCF3, ClO4, SbF6, PF6 or OSO2CF3). [claim2] 4. A catalyst obtained by mixing a ligand comprising a chiral bipyridine compound or its antipode and Bi(OTf)3. [claim3] 2. A method described in claim 1 wherein said ligand comprising the chiral bipyridine compound is represented by the following formula (Chemical Formula 2) (in the formula R1 represents an alkyl group with four or fewer carbon atoms or a phenyl group). [claim4] 3. The method described in claim 1 wherein the molar ratio represented by (said ligand comprising the chiral bipyridine compound or its antipode/said Lewis acid) is at least 2.5. [claim5] 5. The method described in claim 2, wherein the molar ratio represented by (said ligand comprising the chiral bipyridine compound or its antipode/said Lewis acid) is at least 2.5. [claim6] 6. The method described in claim 1, wherein a 2,2'-bipyridine is also added as an additive. [claim7] 7. The method described in claim 2, wherein a 2,2'-bipyridine is also added as an additive. [claim8] 8. The method described in claim 3, wherein a 2,2'-bipyridine is also added as an additive. |
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| 国際特許分類(IPC) |
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| 参考情報 （研究プロジェクト等） | ERATO KOBAYASHI Highly Functionalized Reaction Environments AREA |
日本語項目の表示
| 発明の名称 | 光学活性ヒドロキシメチル化化合物の製法及びそのための触媒 |
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