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Method for manufacturing an optically active hydroxymethylated compound and a catalyst therefore

外国特許コード	F110003812
整理番号	E07612WO
掲載日	2011年7月5日
出願国	アメリカ合衆国
出願番号	79552506
公報番号	20080139835
公報番号	7541307
出願日	平成18年1月27日(2006.1.27)
公報発行日	平成20年6月12日(2008.6.12)
公報発行日	平成21年6月2日(2009.6.2)
国際出願番号	JP2006301293
国際公開番号	WO2006080425
国際出願日	平成18年1月27日(2006.1.27)
国際公開日	平成18年8月3日(2006.8.3)
優先権データ	特願2005-022643 (2005.1.31) JP 2006WO-JP301293 (2006.1.27) WO
発明の名称（英語）	Method for manufacturing an optically active hydroxymethylated compound and a catalyst therefore
発明の概要（英語）	(US7541307) A silicon enolate represented by the following formula (Formula 1) (in the formula, R5 to R7 represent hydrogen atoms, aliphatic hydrocarbon groups, monocyclic or polycyclic alicyclic hydrocarbon groups, monocyclic or polycyclic aromatic or aromatic-aliphatic hydrocarbon groups or heterocyclic groups, R5 and R7 are different, R6 is not a hydrogen atom, each R8 may be identical or different and represents a methyl group, ethyl group or isopropyl group) and formaldehyde are allowed to react in an aqueous solution or a mixed solvent of water and an organic solvent in the presence of a catalyst obtained by mixing a ligand comprising a chiral bipyridine compound or its antipode and Bi(OTf)3.
特許請求の範囲（英語）	[claim1] 1. A method for manufacturing an optically active hydroxymethylated compound that allows a silicon enolate represented by the following formula (Formula 1) (in the formula, R5 to R7 represent hydrogen atoms, aliphatic hydrocarbon groups, monocyclic or polycyclic alicyclic hydrocarbon groups, monocyclic or polycyclic aromatic or aromatic-aliphatic hydrocarbon groups or heterocyclic groups, R5 and R7 are different, R6 is not a hydrogen atom, each R8 may be identical or different and represents a methyl group, ethyl group or isopropyl group) and formaldehyde to react in an aqueous solution or in a mixed solvent of water and an organic solvent or in a mixed solvent of water and organic solvents in the presence of a catalyst obtained by blending a ligand comprising a chiral bipyridine compound or its antipode and a Lewis acid represented by BiY3 (in the formula, Y represents a halogen atom, OAc, OCOCF3, ClO4, SbF6, PF6 or OSO2CF3). [claim2] 4. A catalyst obtained by mixing a ligand comprising a chiral bipyridine compound or its antipode and Bi(OTf)3. [claim3] 2. A method described in claim 1 wherein said ligand comprising the chiral bipyridine compound is represented by the following formula (Chemical Formula 2) (in the formula R1 represents an alkyl group with four or fewer carbon atoms or a phenyl group). [claim4] 3. The method described in claim 1 wherein the molar ratio represented by (said ligand comprising the chiral bipyridine compound or its antipode/said Lewis acid) is at least 2.5. [claim5] 5. The method described in claim 2, wherein the molar ratio represented by (said ligand comprising the chiral bipyridine compound or its antipode/said Lewis acid) is at least 2.5. [claim6] 6. The method described in claim 1, wherein a 2,2'-bipyridine is also added as an additive. [claim7] 7. The method described in claim 2, wherein a 2,2'-bipyridine is also added as an additive. [claim8] 8. The method described in claim 3, wherein a 2,2'-bipyridine is also added as an additive.
発明者/出願人（英語）	KOBAYASHI SHU MANABE KEI JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)	B01J 31/00 水素化物，配位錯体または有機化合物からなる触媒 C07C 45/00 炭素原子または水素原子のみに結合している＞Ｃ＝Ｏ基をもつ化合物の製造；それらの化合物のキレートの製造 C07C 49/00 ケトン；ケテン；二量化ケテン；ケトン性キレート
参考情報（研究プロジェクト等）	ERATO KOBAYASHI Highly Functionalized Reaction Environments AREA

日本語項目の表示

発明の名称	光学活性ヒドロキシメチル化化合物の製法及びそのための触媒

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『 Method for manufacturing an optically active hydroxymethylated compound and a catalyst therefore 』に関するお問合せ

国立研究開発法人科学技術振興機構（ＪＳＴ）知的財産マネジメント推進部
URL: http://www.jst.go.jp/chizai/
E-mail:
Address: 〒102-8666 東京都千代田区四番町5-3
TEL: 03-5214-8293
FAX: 03-5214-8476

Method for manufacturing an optically active hydroxymethylated compound and a catalyst therefore

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