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Catalyst and reaction process UPDATE

外国特許コード F110003815
整理番号 E07615WO
掲載日 2011年7月5日
出願国 アメリカ合衆国
出願番号 86505309
公報番号 20110054190
公報番号 8222177
出願日 平成21年1月28日(2009.1.28)
公報発行日 平成23年3月3日(2011.3.3)
公報発行日 平成24年7月17日(2012.7.17)
国際出願番号 JP2009051322
国際公開番号 WO2009096409
国際出願日 平成21年1月28日(2009.1.28)
国際公開日 平成21年8月6日(2009.8.6)
優先権データ
  • 特願2008-015906 (2008.1.28) JP
  • 2009WO-JP51322 (2009.1.28) WO
発明の名称 (英語) Catalyst and reaction process UPDATE
発明の概要(英語) (US8222177)
Disclosed is a technology for enabling an efficient asymmetric Michael addition reaction which does not require a large amount of a malonic ester, while having a short reaction time.
Specifically disclosed is a catalyst which is composed of MX2 (wherein M is Be, Mg, Ca, Sr, Ba or Ra and X is an arbitrary group) and a compound represented by general formula [I]. [In the formula, R7, R8, R9 and R10 each represents a substituted cyclic group or an unsubstituted cyclic group.]
特許請求の範囲(英語) [claim1]
1. A reaction method, comprising reacting a compound represented by formula [II] with a compound represented by formula [III] in the presence of a catalyst configured using MX2 and a compound represented by formula [I], to form a compound of formula [IV]:
wherein:
R1, R2, R3 and R4 individually represent a H or a hydrocarbon;
W1, W2 and W3 individually represent an electron-withdrawing group selected from the group consisting of an ester group, a carboxyl group, a carbonyl group, a nitrile group and a nitro group;
M is Sr;
X is an alkoxide group, an amide group, or a hexamethyldisilazide group; and
R7, R8, R9, and R10 each represents a substituted cyclic group or a unsubstituted cyclic group and wherein optionally R9 and R10 form a ring.
[claim2]
2. A reaction method according to claim 1, wherein said MX2 is M(OR5)2 wherein M is Sr and R5 is an alkyl group.
[claim3]
3. A reaction method according to claim 1, wherein said MX2 is Sr(OR5)2 and R5 is an alkyl group having a carbon number of 1 to 10.
[claim4]
4. A reaction method according to claim 1, wherein said X is an amide group.
[claim5]
5. A reaction method according to claim 1, wherein said X is hexamethyldisilazide.
[claim6]
6. A reaction method according to claim 1, wherein said cyclic group is an aromatic group.
[claim7]
7. A reaction method according to claim 1, wherein the compound represented by said general formula [I] and M of said compound MX2 are coordinate-bonded to each other.
[claim8]
8. A reaction method according to claim 1, wherein said electron-withdrawing group is an ester group or a carbonyl group.
[claim9]
9. A reaction method according to claim 1, wherein the compound represented by said general formula [II] is a dicarboxylate ester.
[claim10]
10. A reaction method according to claim 1, wherein the compound represented by said general formula [II] is a malonic ester.
[claim11]
11. A reaction method according to claim 1, wherein the compound represented by said general formula [III] is an enone.
[claim12]
12. A reaction method according to claim 1, wherein an aromatic hydrocarbon solvent is used as a solvent of said reaction.
  • 発明者/出願人(英語)
  • KOBAYASHI SHU
  • AGOSTINHO MAGNO
  • SCHNEIDER UWE
  • YAMAGUCHI MIYUKI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
参考情報 (研究プロジェクト等) ERATO KOBAYASHI Highly Functionalized Reaction Environments AREA
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