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Diamino acid derivative starting material, manufacturing method thereof, and diamino acid derivative manufacturing method UPDATE

外国特許コード F110003816
整理番号 E07616WO
掲載日 2011年7月5日
出願国 アメリカ合衆国
出願番号 92200809
公報番号 20110071310
公報番号 8563765
出願日 平成21年2月27日(2009.2.27)
公報発行日 平成23年3月24日(2011.3.24)
公報発行日 平成25年10月22日(2013.10.22)
国際出願番号 JP2009053681
国際公開番号 WO2009113409
国際出願日 平成21年2月27日(2009.2.27)
国際公開日 平成21年9月17日(2009.9.17)
優先権データ
  • 特願2008-058993 (2008.3.10) JP
  • 2009WO-JP53681 (2009.2.27) WO
発明の名称 (英語) Diamino acid derivative starting material, manufacturing method thereof, and diamino acid derivative manufacturing method UPDATE
発明の概要(英語) (US8563765)
Provided is an efficient technology for synthesizing diamino acids (diamino acid derivatives).
Disclosed is a manufacturing method for diamino acid derivatives wherein the fluorenyl groups of the diamino acid derivative starting materials represented by General Formula [II] or [IV] are removed.
特許請求の範囲(英語) [claim1]
1. A method of manufacturing a compound of formula [IV]:
wherein
R1 is a substituted hydrocarbon group or an unsubstituted hydrocarbon group,
R3 is a substituted hydrocarbon group, a substituted heterocyclic group, an unsubstituted hydrocarbon group, or an unsubstituted heterocyclic group,
R4 is an electron-withdrawing group, and
the fluorenyl group is a ring-substituted fluorenyl group or a ring-unsubstituted fluorenyl group,
the method comprising reacting a compound of formula [III]:
with a compound of formula [V]:
wherein
R3 is a substituted hydrocarbon group, a substituted heterocyclic group, an unsubstituted hydrocarbon group, or an unsubstituted heterocyclic group, and
R4 is an electron-withdrawing group.
[claim2]
2. The method of claim 1, wherein R1 is a hydrocarbon group having a carbon number of 1 to 8.
[claim3]
3. The method of claim 1, wherein R2 is a hydrocarbon group having a carbon number of 1 to 8.
[claim4]
4. The method of claim 1, wherein R3 is a hydrocarbon group having a carbon number of 1 to 8 or a heterocyclic group having a carbon number of 1 to 8.
[claim5]
5. The method of claim 1, wherein the electron-withdrawing group is an alkoxycarbonyl group, an acyl group, an arylsulfonyl group, or an alkylsulfonyl group.
[claim6]
6. The method of claim 1, wherein the reacting is conducted in the presence of an optically active basic catalyst.
[claim7]
7. The method of claim 6, wherein the optically active basic catalyst is an optically active guanidine compound.
  • 発明者/出願人(英語)
  • KOBAYASHI SHU
  • YAMASHITA YASUHIRO
  • SEKI KAZUTAKA
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
参考情報 (研究プロジェクト等) ERATO KOBAYASHI Highly Functionalized Reaction Environments AREA
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