Top > Search of International Patents > Diamino acid derivative starting material, manufacturing method thereof, and diamino acid derivative manufacturing method

Diamino acid derivative starting material, manufacturing method thereof, and diamino acid derivative manufacturing method

Foreign code F110003816
File No. E07616WO
Posted date Jul 5, 2011
Country United States of America
Application number 92200809
Gazette No. 20110071310
Gazette No. 8563765
Date of filing Feb 27, 2009
Gazette Date Mar 24, 2011
Gazette Date Oct 22, 2013
International application number JP2009053681
International publication number WO2009113409
Date of international filing Feb 27, 2009
Date of international publication Sep 17, 2009
Priority data
  • P2008-058993 (Mar 10, 2008) JP
  • 2009WO-JP53681 (Feb 27, 2009) WO
Title Diamino acid derivative starting material, manufacturing method thereof, and diamino acid derivative manufacturing method
Abstract (US8563765)
Provided is an efficient technology for synthesizing diamino acids (diamino acid derivatives).
Disclosed is a manufacturing method for diamino acid derivatives wherein the fluorenyl groups of the diamino acid derivative starting materials represented by General Formula [II] or [IV] are removed.
Scope of claims [claim1]
1. A method of manufacturing a compound of formula [IV]:
wherein
R1 is a substituted hydrocarbon group or an unsubstituted hydrocarbon group,
R3 is a substituted hydrocarbon group, a substituted heterocyclic group, an unsubstituted hydrocarbon group, or an unsubstituted heterocyclic group,
R4 is an electron-withdrawing group, and
the fluorenyl group is a ring-substituted fluorenyl group or a ring-unsubstituted fluorenyl group,
the method comprising reacting a compound of formula [III]:
with a compound of formula [V]:
wherein
R3 is a substituted hydrocarbon group, a substituted heterocyclic group, an unsubstituted hydrocarbon group, or an unsubstituted heterocyclic group, and
R4 is an electron-withdrawing group.
[claim2]
2. The method of claim 1, wherein R1 is a hydrocarbon group having a carbon number of 1 to 8.
[claim3]
3. The method of claim 1, wherein R2 is a hydrocarbon group having a carbon number of 1 to 8.
[claim4]
4. The method of claim 1, wherein R3 is a hydrocarbon group having a carbon number of 1 to 8 or a heterocyclic group having a carbon number of 1 to 8.
[claim5]
5. The method of claim 1, wherein the electron-withdrawing group is an alkoxycarbonyl group, an acyl group, an arylsulfonyl group, or an alkylsulfonyl group.
[claim6]
6. The method of claim 1, wherein the reacting is conducted in the presence of an optically active basic catalyst.
[claim7]
7. The method of claim 6, wherein the optically active basic catalyst is an optically active guanidine compound.
  • Inventor, and Inventor/Applicant
  • KOBAYASHI SHU
  • YAMASHITA YASUHIRO
  • SEKI KAZUTAKA
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
IPC(International Patent Classification)
Reference ( R and D project ) ERATO KOBAYASHI Highly Functionalized Reaction Environments AREA
Please contact us by E-mail or facsimile if you have any interests on this patent.

PAGE TOP

close
close
close
close
close
close