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Control of function of intracellular Ca ion UPDATE

外国特許コード F110003824
整理番号 I018P002US2
掲載日 2011年7月5日
出願国 アメリカ合衆国
出願番号 81158807
公報番号 20080064082
公報番号 7709441
出願日 平成19年6月11日(2007.6.11)
公報発行日 平成20年3月13日(2008.3.13)
公報発行日 平成22年5月4日(2010.5.4)
国際出願番号 JP2003014004
国際公開番号 WO2004103393
国際出願日 平成15年10月31日(2003.10.31)
国際公開日 平成16年12月2日(2004.12.2)
優先権データ
  • 特願2003-141083 (2003.5.19) JP
  • 2003WO-JP14004 (2003.10.31) WO
  • 2005US-11283193 (2005.11.18) US
発明の名称 (英語) Control of function of intracellular Ca ion UPDATE
発明の概要(英語) (US7709441)
Analysis of substance capable of binding with inositol-1,4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R.
In particular, control of the activity of intracellular Ca2+ release.
More specifically, a regulator for the activity of inositol-1,4,5-triphosphate (IP3) receptor (IP3R), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calcium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.
特許請求の範囲(英語) [claim1]
1. A method of reducing intracellular calcium release in a cell comprising adding carbonic anhydrase-related protein (CARP) to the cell wherein the carbonic anhydrase-related protein consists of an amino acid sequence of amino acids 45 to 291 of SEQ ID NO: 2, thereby the intracellular release of calcium is reduced.
[claim2]
2. The method of claim 1 wherein the carbonic anhydrase-related protein is added into the cell as a protein.
[claim3]
3. The method of claim 1, wherein the CARP binds to inositol-1,4,5,-triphosphate receptor in endoplasmic reticulum in the cell.
[claim4]
4. A method of controlling intracellular calcium release in a cell comprising expressing a carbonic anhydrase-related protein (CARP) from an expression construct in the cell wherein the carbonic anhydrase-related protein comprises an amino acid sequence of amino acids 45 to 291 of SEQ ID NO: 2, whereby the intracellular release of calcium is controlled.
  • 発明者/出願人(英語)
  • MIKOSHIBA KATSUHIKO
  • HIROTA JUNJI
  • ANDO HIDEAKI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
米国特許分類/主・副
  • A61K038/17A2
  • C07K014/47A1
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