Control of function of intracellular Ca ion
|Posted date||Jul 5, 2011|
|Country||United States of America|
|Date of filing||Jun 11, 2007|
|Gazette Date||Mar 13, 2008|
|Gazette Date||May 4, 2010|
|International application number||JP2003014004|
|International publication number||WO2004103393|
|Date of international filing||Oct 31, 2003|
|Date of international publication||Dec 2, 2004|
|Title||Control of function of intracellular Ca ion|
Analysis of substance capable of binding with inositol-1,4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R.
In particular, control of the activity of intracellular Ca2+ release.
More specifically, a regulator for the activity of inositol-1,4,5-triphosphate (IP3) receptor (IP3R), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calcium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.
|Scope of claims||
1. A method of reducing intracellular calcium release in a cell comprising adding carbonic anhydrase-related protein (CARP) to the cell wherein the carbonic anhydrase-related protein consists of an amino acid sequence of amino acids 45 to 291 of SEQ ID NO: 2, thereby the intracellular release of calcium is reduced.
2. The method of claim 1 wherein the carbonic anhydrase-related protein is added into the cell as a protein.
3. The method of claim 1, wherein the CARP binds to inositol-1,4,5,-triphosphate receptor in endoplasmic reticulum in the cell.
4. A method of controlling intracellular calcium release in a cell comprising expressing a carbonic anhydrase-related protein (CARP) from an expression construct in the cell wherein the carbonic anhydrase-related protein comprises an amino acid sequence of amino acids 45 to 291 of SEQ ID NO: 2, whereby the intracellular release of calcium is controlled.
|IPC(International Patent Classification)||
Contact Information for " Control of function of intracellular Ca ion "
- Japan Science and Technology Agency Department of Intellectual Property Management
- URL: http://www.jst.go.jp/chizai/
- Address: 5-3, Yonbancho, Chiyoda-ku, Tokyo, Japan , 102-8666
- Fax: 81-3-5214-8476