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Control of function of intracellular Ca ion

Foreign code F110003824
File No. I018P002US2
Posted date Jul 5, 2011
Country United States of America
Application number 81158807
Gazette No. 20080064082
Gazette No. 7709441
Date of filing Jun 11, 2007
Gazette Date Mar 13, 2008
Gazette Date May 4, 2010
International application number JP2003014004
International publication number WO2004103393
Date of international filing Oct 31, 2003
Date of international publication Dec 2, 2004
Priority data
  • P2003-141083 (May 19, 2003) JP
  • 2003WO-JP14004 (Oct 31, 2003) WO
  • 2005US-11283193 (Nov 18, 2005) US
Title Control of function of intracellular Ca ion
Abstract (US7709441)
Analysis of substance capable of binding with inositol-1,4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R.
In particular, control of the activity of intracellular Ca2+ release.
More specifically, a regulator for the activity of inositol-1,4,5-triphosphate (IP3) receptor (IP3R), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calcium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.
Scope of claims [claim1]
1. A method of reducing intracellular calcium release in a cell comprising adding carbonic anhydrase-related protein (CARP) to the cell wherein the carbonic anhydrase-related protein consists of an amino acid sequence of amino acids 45 to 291 of SEQ ID NO: 2, thereby the intracellular release of calcium is reduced.
[claim2]
2. The method of claim 1 wherein the carbonic anhydrase-related protein is added into the cell as a protein.
[claim3]
3. The method of claim 1, wherein the CARP binds to inositol-1,4,5,-triphosphate receptor in endoplasmic reticulum in the cell.
[claim4]
4. A method of controlling intracellular calcium release in a cell comprising expressing a carbonic anhydrase-related protein (CARP) from an expression construct in the cell wherein the carbonic anhydrase-related protein comprises an amino acid sequence of amino acids 45 to 291 of SEQ ID NO: 2, whereby the intracellular release of calcium is controlled.
  • Inventor, and Inventor/Applicant
  • MIKOSHIBA KATSUHIKO
  • HIROTA JUNJI
  • ANDO HIDEAKI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
IPC(International Patent Classification)
U.S. Cl./(Sub)
  • A61K038/17A2
  • C07K014/47A1
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