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Method for determination of absolute configuration of chiral compounds 実績あり

外国特許コード F110003827
整理番号 I019P001WO
掲載日 2011年7月5日
出願国 アメリカ合衆国
出願番号 54449604
公報番号 20060148091
公報番号 7736902
出願日 平成16年2月6日(2004.2.6)
公報発行日 平成18年7月6日(2006.7.6)
公報発行日 平成22年6月15日(2010.6.15)
国際出願番号 JP2004001267
国際公開番号 WO2004070364
国際出願日 平成16年2月6日(2004.2.6)
国際公開日 平成16年8月19日(2004.8.19)
優先権データ
  • 特願2003-029190 (2003.2.6) JP
  • 2004WO-JP01267 (2004.2.6) WO
発明の名称 (英語) Method for determination of absolute configuration of chiral compounds 実績あり
発明の概要(英語) (US7736902)
The present invention provides a simple, highly sensitive, and highly precise method for determining the absolute configuration of a chiral compound such as a diamine or an amino alcohol.
The present invention is directed to a method for determining the absolute configuration of an asymmetric carbon of a chiral compound on the basis of the sign of the Cotton effect by analyzing a solution containing the chiral compound and a porphyrin dimer by circular dichroism spectroscopy.
特許請求の範囲(英語) [claim1]
1. A method for determining the absolute configuration of an asymmetric carbon of a chiral compound on the basis of the sign of the Cotton effect by analyzing a solution containing the chiral compound and a porphyrin dimer by circular dichroism spectroscopy, wherein the porphyrin dimer:
(a) has a carbon chain-crosslinked porphyrin dimer structure,
(b) is such that one porphyrin ring of the dimer has a Zn2+ metal center and the other porphyrin ring of the dimer is a free porphyrin ring, and
(c) is such that the free porphyrin ring has a methyl group or substituent bulkier than a methyl group at one or more of the second carbons from the carbon bonded to the crosslinking carbon chain around the outer periphery of the free porphyrin ring, and
the chiral compound:
(i) is capable of coordinating to the porphyrin dimer,
(ii) has an asymmetric carbon directly bonded to a group capable of coordinating to the porphyrin dimer, or an asymmetric carbon adjacent to the carbon atom bonded to a group capable of coordinating to the porphyrin dimer, and
(iii) is a diamine or an amino alcohol.
[claim2]
2. The method according to claim 1, wherein the porphyrin dimer is a compound represented by the following formula (1):
Formula 1
wherein M2+ is Zn2+,
n is 2 or 3,
Ra to Rd are the same or different and are each a hydrogen atom or a methyl group or substituent bulkier than a methyl group,
either Rc or Rd is a methyl group or substituent bulkier than a methyl group, and
R1 to R12 are the same or different and are each a hydrogen atom or a methyl group or substituent bulkier than a methyl group.
[claim3]
3. The method according to claim 2, wherein either Rc or Rd in Formula 1 is selected from the group consisting of 1) a C1 to C8 hydrocarbon group, 2) an oxygen-containing substituent, 3) a nitrogen-containing substituent, 4) a halogen atom, and 5) a halogenated hydrocarbon group.
[claim4]
4. The method according to claim 1, wherein the porphyrin dimer is a compound represented by the following formula (2):
Formula 2.
  • 発明者/出願人(英語)
  • INOUE YOSHIHISA
  • BOROVKOV VICTOR V
  • HEMBURY GUY A
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
米国特許分類/主・副
  • G01N021/19
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