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Method for determination of presence or absence of peptide compound PYY3-36

外国特許コード F110003830
整理番号 I019P006US1
掲載日 2011年7月6日
出願国 アメリカ合衆国
出願番号 46388909
公報番号 20100009453
公報番号 7993929
出願日 平成21年5月11日(2009.5.11)
公報発行日 平成22年1月14日(2010.1.14)
公報発行日 平成23年8月9日(2011.8.9)
優先権データ
  • 特願2006-304529 (2006.11.9) JP
  • 2007WO-JP70785 (2007.10.25) WO
発明の名称 (英語) Method for determination of presence or absence of peptide compound PYY3-36
発明の概要(英語) (US7993929)
The present invention provides a method for determining in a pharmaceutical test formulation the presence or absence of a peptide compound PYY3-36 represented by the following amino acid sequence: H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-X (SEQ ID NO: 1), wherein X is OH or a carboxy acid-protecting group, the method comprising (1) preparing a solution by mixing the pharmaceutical test formulation with cucurbit[7]uril in a solvent; and (2) thermally analyzing the solution prepared in Step (1).
特許請求の範囲(英語) [claim1]
1. A method for determining in a pharmaceutical test formulation the presence or absence of a peptide compound PYY3-36 represented by the following amino acid sequence: H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-X (SEQ ID NO: 1), wherein X is OH or a carboxy acid-protecting group, the method comprising: (1) preparing a solution by mixing the pharmaceutical test formulation with cucurbit[7]uril in a solvent; and
(2) thermally analyzing the solution prepared in Step (1)
wherein generation of heat by the solution prepared in Step (1) evidences the existence of H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-X, wherein X is OH or a carboxy acid-protecting group.
[claim2]
2. The determination method according to claim 1, wherein the presence or absence of a peptide compound PYY1-36 represented by the following amino acid sequence: H-Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2 (SEQ ID NO: 2), and/or peptide digests generated by degradation of the peptide compound PYY1-36 is determined.
[claim3]
3. The determination method according to claim 1, wherein peptide digests generated by degradation of the peptide compound PYY3-36 is detected.
  • 発明者/出願人(英語)
  • INOUE YOSHIHISA
  • REKHARSKY MIKHAIL
  • KIM KIMOON
  • KO YONG HO
  • SELVAPALAM NARAYANAN
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
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