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Novel bisboron compound

Foreign code F110003962
File No. I018P007WO
Posted date Jul 7, 2011
Country EPO
Application number 06833296
Gazette No. 1961756
Gazette No. 1961756
Date of filing Nov 24, 2006
Gazette Date Aug 27, 2008
Gazette Date Apr 27, 2016
International application number JP2006323492
International publication number WO2007061074
Date of international filing Nov 24, 2006
Date of international publication May 31, 2007
Priority data
  • P2005-340864 (Nov 25, 2005) JP
  • 2006WO-JP323492 (Nov 24, 2006) WO
Title Novel bisboron compound
Abstract (EP1961756)
A bisboron compound represented by the general formula (I): wherein B represents a boron atom, Y represents an oxygen or sulfur atom, R 1 and R 2 independently represent a monocyclic aromatic group, a polycyclic aromatic group, or a heterocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur atoms, R 3 represents a hydrogen atom; -(CH 2 ) m -NR 4 R 5 ; -CO-(CH 2 ) m -NR 4 R 5 ; - COCH(NH 2 )R 6 ; -CHR 7 R 8 ; -CH 2 CH(NH 2 )-R 9 ; quinolyl substituted with C1-C4 alkyl group; or C1-C4 alkyl substituted with pyridyl, piperidino or pyrrolidinyl group, and X represents a monocyclic atomatic group, a polycyclic aromatic group or a heterocyclic group, which may be the same as or different from R 1 and R 2 , or a bifunctional group having a monocyclic aromatic group, polycyclic aromatic group or heterocyclic group bonded to each side of a group selected from the group consisting of a single bond, O, CH 2 , S, SO 2 , CH 2 OCH 2 , OCH 2 , OCH 2 CH 2 OCH 2 , OCH 2 OCH 2 CH 2 and CH 2 OCH 2 CH 2 , or a salt thereof, and a composition for controlling the intracellular calcium concentration, which comprises the compound or salt thereof as an active ingredient.
Scope of claims [claim1]
1. A bisboron compound represented by the general formula (I): (see diagramm) wherein B represents a boron atom, Y represents an oxygen or sulfur atom, R 1 and R 2 independently represent a monocyclic aromatic group, a polycyclic aromatic group, or a heterocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur atoms, R 3 represents a hydrogen atom;
-(CH 2) m-NR 4R 5, wherein m represents an integer of 1 to 4, and R 4 and R 5 independently represent a hydrogen atom, or C1-C4 alkyl substituted or unsubstituted with amino, mono- or di-C1-C4 alkylamino or phenyl group, or R 4 and R 5 are taken together with the nitrogen atom to which they are bonded to form a 5- or 6-membered cyclic ring;
-CO-(CH 2) m-NR 4R 5, wherein m, R 4 and R 5 are as defined above;
- COCH(NH 2)R 6, wherein R 6 represents an amino acid residue or -(CH 2) nNH 2, wherein n represents an integer of 1 to 3;
-CHR 7R 8, wherein R 7 and R 8 independently represent C1-C4 alkyl substituted or unsubstituted with amino, mono- or di-(amino group-substituted or unsubstituted C1-C4 alkyl)amino or phenyl group, pyridyl, or phenyl substituted with C1-C3 alkoxy group;
-CH 2CH(NH 2)-R 9, wherein R 9 represents phenyl, or C1-C4 alkyl substituted with phenyl group;
quinolyl or isoquinolyl substituted with C1-C4 alkyl group;
or C1-C4 alkyl substituted with pyridyl, piperidino or pyrrolidinyl group, and X represents a monocyclic aromatic group, a polycyclic aromatic group or a heterocyclic group, which may be the same as or different from R 1 and R 2, or a bifunctional group having a monocyclic aromatic group, polycyclic aromatic group or heterocyclic group bonded to each side of a group selected from the group consisting of a single bond, O, CH 2, S, SO 2, CH 2OCH 2, OCH 2, OCH 2CH 2OCH 2, OCH 2OCH 2CH 2 and CH 2OCH 2CH 2, or a salt thereof,
provided that bis[2-(hydroxyphenylboryl)benzyl] ether, 1,4-bis(4-(hydroxyphenylboryl)phenoxy)butane, bis[4-(hydroxyphenylboryl)benzyl] ether, bis[2-[(2-aminoethoxy)phenylboryl]benzyl] ether, bis[4-((2-aminoethoxy)phenylboryl)benzyl] ether, [4-[(2-aminoethoxy)phenylboryl]benzyl] [2-[4-[(2-aminoethoxy)phenylboryl]phenyl]ethyl] ether, [2-[(2-aminoethoxy)phenylboryl]benzyl] [2-[4-[(2-aminoethoxy)phenylboryl]phenyl]ethyl] ether and salts thereof are excluded.
[claim2]
2. The bisboron compound or salt thereof according to claim 1, wherein the monocyclic aromatic group or polycyclic aromatic group is an aromatic group substituted or unsubstituted with at least one substituent selected from the group consisting of halogen, halogenated C1-C4 alkyl, cyano, hydroxy, sulfanyl, amino, nitro, mono- or di-C1-C4 alkylamino, carboxyl, C1-C4 alkylcarbonyl, C1-C4 alkylcarbonyloxy, C2-C4 alkenyl, C2-C4 alkynyl, cycloalkyl, cycloalkenyl, C1-C4 alkyl, C1-C4 alkylthio, C1-C4 alkoxy, aryl, amide and C1-C4 alkylamide.
[claim3]
3. The bisboron compound or salt thereof according to claim 1, wherein the heterocyclic group is a 5- to 15-membered heterocyclic group substituted or unsubstituted with at least one substituent selected from the group consisting of halogen, cyano, hydroxy, sulfanyl, amino, nitro, mono- or di-C1-C4 alkylamino, carboxyl, C1-C4 alkylcarbonyl, C1-C4 alkylcarbonyloxy, C2-C4 alkenyl, C2-C4 alkynyl, cycloalkyl, cycloalkenyl, C1-C4 alkyl, C1-C4 alkylthio, C1-C4 alkoxy, aryl, amide and C1-C4 alkylamide.
[claim4]
4. The bisboron compound or salt thereof according to claim 1, wherein the X is a group selected from the group consisting of the following groups. (see diagramm)(see diagramm)(see diagramm)(see diagramm)(see diagramm)(see diagramm)(see diagramm)(see diagramm)
[claim5]
5.
The bisboron compound or salt thereof according to claim 1, wherein the X is substituted or unsubstituted diphenyl ether, dibenzyl ether, phenyl benzyl ether, benzyl phenethyl ether, phenoxyethyl benzyl ether or diphenyl, having a meta-meta, ortho-ortho, para-para, meta-para, meta-ortho or ortho-para orientation.
[claim6]
6. The bisboron compound or salt thereof according to claim 5, wherein the X is diphenyl ether having any of meta-meta, ortho-ortho, para-para, ortho-para, ortho-meta and meta-para orientations.
[claim7]
7. The bisboron compound or salt thereof according to claim 6, wherein the X is diphenyl ether having a meta-meta, ortho-ortho or para-para orientation.
[claim8]
8. The bisboron compound or salt thereof according to claim 5, wherein the X is dibenzyl ether having any of meta-meta, ortho-para, ortho-meta and meta-para orientations.
[claim9]
9. The bisboron compound or salt thereof according to claim 8, wherein the X is dibenzyl ether having a meta-meta orientation.
[claim10]
10. The bisboron compound or salt thereof according to claim 5, wherein the X is benzyl phenethyl ether having any of meta-meta, ortho-ortho, ortho-meta and meta-para orientations.
[claim11]
11. The bisboron compound or salt thereof according to claim 10, wherein the X is benzyl phenethyl ether having a meta-meta or ortho-ortho orientation.
[claim12]
12. The bisboron compound or salt thereof according to claim 1, wherein the R 1 and R 2 are independently a substituted or unsubstituted phenyl or phenylene group.
[claim13]
13. The bisboron compound or salt thereof according to claim 1, wherein the R 3 is a hydrogen atom or a 2-aminoethyl group.
[claim14]
14. The bisboron compound or salt thereof according to claim 1, wherein the Y is an oxygen atom.
[claim15]
15. The bisboron compound according to claim 1, wherein the compound is selected from the group consisting of: bis(4,4'-(phenylhydroxyboryl)phenyl) ether;
bis(4,4'-(phenylaminoethoxyboryl)phenyl) ether;
bis(4,4'-(3-chloro-4-methylphenylhydroxyboryl)benzyl) ether;
bis(3,3'-(phenylhydroxyboryl)benzyl) ether;
bis(3,3'-(phenylaminoethoxyboryl)benzyl) ether;
bis(4-(4-trifluoromethylphenylhydroxyboryl)benzyl) ether;
bis(4-(1-naphthylhydroxyboryl)benzyl) ether;
bis(4-(fluorophenylhydroxyboryl)benzyl) ether;
bis(3-(4-methoxyphenylhydroxyboryl)benzyl) ether;
(3-(phenylhydroxyboryl)benzyl) (4-(phenylhydroxyboryl)benzyl) ether;
(2-(phenylhydroxyboryl)benzyl) (3-(phenylhydroxyboryl)benzyl) ether;
(2-(phenylhydroxyboryl)benzyl) (4-(phenylhydroxyboryl)benzyl) ether;
(3-(phenylaminoethoxyboryl)benzyl) (4-(phenylaminoethoxyboryl)benzyl) ether;
bis(3-(3-chloro-4-methylphenylhydroxyboryl)benzyl) ether;
(2-(phenylaminoethoxyboryl)benzyl) (3-(phenylaminoethoxyboryl)benzyl) ether;
2-(phenylaminoethoxyboryl)benzyl) (4-(phenylaminoethoxyboryl)benzyl) ether;
bis(3-(4-fluorophenylhydroxyboryl)benzyl) ether;
bis(3-(4-fluorophenylaminoethoxyboryl)benzyl) ether;
bis(4-(4-chloro-3-methyl-phenylhydroxyboryl)benzyl) ether;
bis(4-(4-chloro-3-methyl-phenylaminoethoxyboryl)benzyl) ether;
bis(3-(3',4'-methylenedioxy-phenylhydroxyboryl)benzyl) ether;
(3-(3-chloro-4-methylphenylhydroxyboryl)benzyl) (4-(3-chloro-4-methylphenylhydroxyboryl)benzyl) ether;
(3-(3',4',5'-trifluorophenylhydroxyboryl)benzyl) (4-(3',4',5'-trifluorophenylhydroxyboryl)benzyl) ether;
bis(3-(4-methoxyphenylaminoethoxyboryl)benzyl) ether;
(3-(4-chloro-3-methylphenylhydroxyboryl)benzyl) (2-(4-chloro-3-methylphenylhydroxyboryl)benzyl) ether;
bis(3-(4-cyanophenylhydroxyboryl)benzyl) ether;
bis(3-(2'-thiophenylhydroxyboryl)benzyl) ether;
bis(3-(1'-naphthylhydroxyboryl)benzyl) ether;
bis(3-(2'-thiophenylhydroxyboryl)benzyl) ether;
bis(4-(2-methoxy-5-fluorophenylhydroxyboryl)benzyl) ether;
bis(4-(2-methoxy-5-fluorophenylaminoethoxyboryl)benzyl) ether;
(3-(4-chloro-3-methyl-phenylaminoethoxyboryl)benzyl) (2-(4-chloro-3-methyl-phenylaminoethoxyboryl)benzyl) ether;
bis(4-(3,4-difluorophenylhydroxyboryl)benzyl) ether;
bis(4-(3,4-difluorophenylaminoethoxyboryl)benzyl) ether;
(3-(3',4',5'-trifluorophenylaminoethoxyboryl)benzyl) (4-(3',4',5'-trifluorophenylaminoethoxyboryl)benzyl) ether;
5,5'-(phenylhydroxyboryl)-2,2'-dithiophene;
5,5'-(phenylaminoethoxyboryl)-2,2'-dithiophene;
3,5-di(phenylaminoethoxyboryl)toluene;
2,5-di(phenylhydroxyboryl)toluene;
2,2'-di(phenylhydroxyboryl)-1,1'-binaphthyl;
2,2'-di(phenylaminoethoxyboryl)-1,1'-binaphthyl;
bis(4-(4-methylphenylhydroxyboryl)benzyl) ether;
bis(4-(4-methylphenylaminoethoxyboryl)benzyl) ether;
4,4'-(4-methylphenylaminoethoxyboryl)diphenyl;
4,4'-(4-methylphenylhydroxyboryl)diphenyl ether;
4,4'-(4-methylphenylaminoethoxyboryl)diphenyl ether;
4,4'-bis(3-chloro-4-methyl-phenylaminoethoxyboryl)phenyl ether;
(2-(phenylhydroxyboryl)phenethyl) ((2-phenylhydroxyboryl)benzyl) ether;
(2-(phenylhydroxyboryl)phenethyl) ((2-phenylaminoethoxyboryl)benzyl) ether;
(4-phenylhydroxyborylphenyl) (4'-phenylhydroxyborylbenzyl) ether;
(4-phenylaminoethoxyborylphenyl) (4'-phenylaminoethoxyborylbenzyl) ether;
(4-(2-thiopheneaminoethoxyboryl)phenoxyethyl) (4'-(2-thiopheneaminoethoxyboryl)benzyl) ether;
(4-trifluoromethylphenylhydroxyborylphenyl) (4'-trifluoromethylphenylhydroxyborylbenzyl) ether;
(4-trifluoromethylphenylaminoethoxyborylphenyl) (4'-trifluoromethylphenylaminoethoxyborylbenzyl) ether;
9,10-bis-(trifluoromethylphenylhydroxyboryl)anthracene;
9,10-bis-(trifluoromethylphenylaminoethoxyboryl)anthracene;
bis(3-(1-naphthylaminoethoxyboryl)benzyl) ether;
4,5-di(phenylhydroxyboryl)-2,7-di-t-butyl-9,9-dimethylxanthrene;
4,5-di(phenylaminoethoxyboryl)-2,7-di-t-butyl-9,9-dimethylxanthrene;
(4-(phenylhydroxyboryl)phenoxyethyl) (4-(phenylhydroxyboryl)benzyl) ether;
(4-(phenylaminoethoxyboryl)phenoxyethyl) (4-(phenylaminoethoxyboryl)benzyl) ether;
6,6'-(phenylhydroxyboryl)-2,2'-dipyridyl;
6,6'-(phenylaminoethoxyboryl)-2,2'-dipyridyl;
bis(2,5-(phenylhydroxyboryl)furan;
bis(2,5-(phenylaminoethoxyboryl)furan;
bis(4,4'-(phenyl-N,N-dimethylaminoethoxyboryl)phenyl) ether;
bis(4,4'-(phenyl-N-methylaminoethoxyboryl)phenyl) ether;
bis(4,4'-(phenyl-glycineboryl)phenyl) ether;
bis(4,4'-(phenyl-glutamineboryl)phenyl) ether;
bis(4,4'-(phenyl-cysteineboryl)phenyl) ether;
bis(4,4'-(phenyl-asparagineboryl)phenyl) ether;
(4-(phenyl-N-methylaminoethylboryl)phenyl) (4'-(hydroxymethylphenyl-N-methylaminoethylboryl)phenyl) ether;
(4-(phenyl-N,N-dimethylaminoethylboryl)phenyl)(4'-(hydroxymethylphenyl-N,N-dimethylaminoethylboryl)phenyl) ether;
(4-(phenyl-glutamic acid boryl)phenyl) (4'-(hydroxymethylphenyl-glutamic acid boryl)phenyl) ether;
(4-(phenyl-glutamineboryl)phenyl) (4'-(hydroxymethylphenyl-glutamineboryl)phenyl) ether;
bis(4,4'-(phenyl-N,N-dimethylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-N-aminoethyl-aminoethoxyboryl)phenyl) ether;
(4-(phenyl-cysteineboryl)phenyl) (4'-(hydroxymethylphenyl-cysteineboryl)phenyl) ether;
bis(4,4'-(phenoxyphenyl-aminoethoxyboryl)phenyl) ether;
bis(4,4'-(phenyl-N-aminoethylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-N-methylaminoethoxyboryl)benzyl) ether;
(4'-trifluoromethylphenyl-N,N-dimethylaminoethoxyboryl)-4-phenyl (4'-trifluoromethylphenyl-N,N-dimethylaminoethoxyboryl)benzyl ether;
(4'-trifluoromethylphenyl-N-methylaminoethoxyboryl)-4-phenyl (4'-trifluoromethylphenyl-N-methylaminoethoxyboryl)-4-benzyl ether;
bis(3,3'-(phenyl-N,N-dimethylaminoethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-asparagineboryl)benzyl) ether;
bis(3,3'-(phenyl-aminothioethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-2-pyridylmethoxyboryl)benzyl) ether;
bis(4,4'-(p-trifluoromethylphenyl-hydroxyboryl)benzyl) ether;
bis(4,4'-(3-chloro-4-methylphenyl-hydroxyboryl)benzyl) ether;
bis(4,4'-(phenyl-lysineboryl)benzyl) ether;
bis(4,4'-(p-methoxymethyl-phenyl-hydroxyboryl)benzyl) ether;
bis(4,4'-(3,4-difluorophenyl-hydroxyboryl)benzyl) ether;
bis(4,4'-(p-methoxyphenyl-aminoethoxyboryl)benzyl) ether;
bis(4,4'-(p-methoxyphenyl-N-methylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(p-methoxyphenyl-N,N-dimethylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(p-methoxyphenyl-2,4-diaminobutyric acid boryl)benzyl) ether;
bis(4,4'-(3,4-difluorophenyl-aminoethoxyboryl)benzyl) ether;
bis(4,4'-(3,4-difluorophenyl-N-methylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(3,4-difluorophenyl-N,N-dimethylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(3,4-difluorophenyl-N-aminoethylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(3-chloro-4-methylphenyl-aminoethoxyboryl)benzyl) ether;
bis(4,4'-(3-chloro-4-methylphenyl-N-methylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(3-chloro-4-methylphenyl-N,N-dimethylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(3-chloro-4-methylphenyl-2-piperidylmethyloxyboryl)benzyl) ether;
bis(4,4'-(p-trifluoromethylphenyl-N,N-dimethylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(p-trifluoromethylphenyl-asparagineboryl)benzyl) ether;
bis(4,4'-(p-trifluoromethylphenyl-aminoethoxyboryl)benzyl) ether;
(4-phenyl-N-methylaminoethoxyborylphenyl) 4'-(N-methylaminoethoxyborylbenzyl) ether;
(4-phenyl-N,N-dimethylaminoethoxyborylphenyl) 4'-(N,N-dimethylaminoethoxyborylbenzyl) ether;
(4-phenyl-2-pyridylmethoxyborylphenyl) (4'-phenyl-2-pyridylmethoxyborylbenzyl) ether;
4-(phenyl-p-methoxyphenyl-2-pyridylmethoxyboryl)-phenyl 4'-(p-methoxyphenyl-2-pyridylmethoxyboryl)benzyl ether;
bis(4,4'-(phenyl-3-piperidyloxyboryl)phenyl) ether;
bis(4,4'-(phenyl-2-pyridylmethoxyboryl)phenyl) ether;
bis(4,4'-(phenyl-aminothioethoxyboryl)phenyl) ether;
bis(4,4'-(phenyl-2-amino-1-phenylethoxyboryl)phenyl) ether;
bis(4,4'-(phenyl-ornithineboryl)phenyl) ether;
bis(4,4'-(phenyl-2,3-diaminopropionic acid boryl)phenyl) ether;
bis(4,4'-(phenyl-lysineboryl)phenyl) ether;
bis(4,4'-(phenyl-2-pyrrolidinemethoxyboryl)phenyl) ether;
bis(4,4'-(naphthylhydroxyboryl)phenyl) ether;
bis(4,4'-(tolylhydroxyboryl)phenyl) ether;
bis(4,4'-(naphthyl-aminoethoxyboryl)phenyl) ether;
bis(4,4'-(naphthyldimethylaminoethoxyboryl)phenyl) ether;
bis(4,4'-(naphthyl-2-pyridylmethoxyboryl)phenyl) ether;
bis(4,4'-(naphthylglutamineboryl)phenyl) ether;
bis(4,4'-(naphthyl-2,4-diaminopropionic acid boryl)phenyl) ether;
bis(4,4'-(tolyldimethylaminoethoxyboryl)phenyl) ether;
bis(4,4'-(tolylpiperazylethoxyboryl)phenyl) ether;
bis(4,4'-(tolylglutamineboryl)phenyl) ether;
bis(4,4'-(tolyllysineboryl)phenyl) ether;
bis(4,4'-(phenyl-2-amino-1-phenylethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-aminothioethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-2-pyrrolidinemethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-2,4-diaminobutyric acid boryl)benzyl) ether;
bis(4,4'-(phenyl-butylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-phenylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-benzylaminoethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-N-methylpiperidine-methoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-1-methyl-2-aminoethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-1-piperidylethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-2-pyrrolidinomethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-aminothioethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-2-phenyl-2-aminoethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-2-piperazylmethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-dimethylaminoethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-1-methyl-2-aminoethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-2-piperidylethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-2-pyridylmethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-2-amino-1-phenylethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-N-methylethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-N-aminoethyl-1-methyl-2-aminoethoxyboryl)benzyl) ether;
bis(3,3'-(phenyl-glutamineboryl)benzyl) ether;
bis(3,3'-(phenyl-2,4-diaminobutyric acid boryl)benzyl) ether;
bis(3,3'-(phenyl-N-butylaminoethylboryl)benzyl) ether;
bis(3,3'-(phenyl-asparagineboryl)benzyl) ether;
bis(3,3'-(phenyl-lysineboryl)benzyl) ether;
bis(3,3'-(phenyl-ornithineboryl)benzyl) ether;
bis(4,4"-(phenyl-2-methyl-8-quinolinooxyboryl)phenyl) ether;
bis(4,4'-(phenyl-2-pyridylmethoxyboryl)phenyl) ether;
bis(4,4'-(phenyl-2-benzyl-2-amino-ethoxyboryl)benzyl) ether;
bis(4,4'-(phenyl-2-benzyl-2-amino-ethoxyboryl)phenyl) ether;
bis(3,3'-(phenyl-2-benzyl-2-amino-ethoxyboryl)phenyl) ether;
bis(4,4'-(phenyl-2-phenyl-2-amino-ethoxyboryl)benzyl) ether;
and salts thereof.
[claim16]
16. A composition for controlling the intracellular calcium concentration, characterized in that the composition comprises the bisboron compound or salt thereof according to any one of claims 1 to 15 as an active ingredient.
[claim17]
17. The composition according to claim 16, which is used for prevention, alleviation or treatment of a disease caused by an increase in the intracellular calcium concentration.
[claim18]
18. The composition according to claim 16, which inhibits release of endogenous calcium and/or entry of capacitative calcium.
[claim19]
19. The composition according to claim 17, wherein the disease is ischemic heart or brain disease, cardiac hypertrophy, renal disease, hypertension, cerebral vasospasm, pancreatitis, asthma, immunodeficiency, allergic disease, or Alzheimer's disease.
  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • Inventor
  • MIKOSHIBA KATSUHIKO
  • OZAKI SHOICHIRO
  • SUZUKI AKINOBU
  • NAKAMURA TAKESHI
IPC(International Patent Classification)
U.S. Cl./(Sub)
  • C07F005/02C
Specified countries (EP1961756)
Contracting States: DE FR GB
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