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TRANSLATION REGULATION SYSTEM IN CELL OR ARTIFICIAL CELL MODEL BY USING LOW-MOLECULAR-WEIGHT RNA

Foreign code F110003967
File No. I029P002WO
Posted date Jul 7, 2011
Country EPO
Application number 08852782
Gazette No. 2221371
Gazette No. 2221371
Date of filing Nov 21, 2008
Gazette Date Aug 25, 2010
Gazette Date Nov 13, 2013
International application number WO2008JP71214
Date of international filing Nov 21, 2008
Priority data
  • P2007-303661 (Nov 22, 2007) JP
Title TRANSLATION REGULATION SYSTEM IN CELL OR ARTIFICIAL CELL MODEL BY USING LOW-MOLECULAR-WEIGHT RNA
Abstract

An object of the present invention is to construct an mRNA which specifically responds to a short RNA sequence and can activate, repress, and regulate the translation of the desired gene, and to construct an artificial cell model system using a liposome comprising the mRNA and a cell-free translational system encapsulated therein. The present invention provides: an mRNA comprising a target RNA-binding site located immediately 5' to the ribosome-binding site, and a nucleotide sequence located 5' to the target RNA-binding site, the nucleotide sequence being complementary to the ribosome-binding site

an mRNA comprising a small RNA-binding site located 3' to the start codon, and a nucleotide sequence located 3' to the small RNA-binding site, the nucleotide sequence encoding a protein

and a liposome comprising any of these mRNAs encapsulated therein.

  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • Inventor
  • INOUE, TAN
  • SAITO, HIROHIDE
  • KATO, YUSHO
  • YOSHIKAWA, KENICHI
  • YAMADA, AYAKO
  • YAMANAKA, TORU
IPC(International Patent Classification)
Specified countries AT,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LI,LT,LU,LV,MC,MT,NL,NO,PL,PT,RO,SE,SI,SK,TR
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