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GENE CARRIERS COMPRISING A BETA-1,3-GLUCAN AND PROCESS FOR PRODUCING THE SAME achieved

Foreign code F110003988
File No. K01202EP
Posted date Jul 7, 2011
Country EPO
Application number 02703955
Gazette No. 1369133
Gazette No. 1369133
Date of filing Mar 11, 2002
Gazette Date Dec 10, 2003
Gazette Date Aug 1, 2012
International application number WO2002JP02228
Date of international filing Mar 11, 2002
Priority data
  • P2001-069655 (Mar 13, 2001) JP
  • P2001-130705 (Apr 27, 2001) JP
Title GENE CARRIERS COMPRISING A BETA-1,3-GLUCAN AND PROCESS FOR PRODUCING THE SAME achieved
Abstract

Disclosed are gene carriers utilizing beta -1,3-glucan and methods of preparing the same. The beta -1,3-glucan has at least one 1,6-glucopyranoside branch and is chemically modified through periodate oxidation and reductive animation so as to impart nucleic acid-binding functional groups (for example, cationic functional groups) to at least some of the 1,6-glucopyranoside branches thereof. Triple helix beta -1,3-glucan is dissolved in a polar organic solvent to form single-stranded beta -1,3-glucan. By replacing, in the presence of a nucleic acid, the polar organic solvent for the solution containing the chemically modified single-stranded beta -1,3-glucan by water, a complex (gene carrier) is formed in which the nucleic acid is bound to double-stranded beta -1,3-glucan. <IMAGE>

  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY CORPORATION
  • KIMURA, TARO
  • MIZU, MASAMI
  • FUKUOKA PREFECTURAL GOVERNMENT
  • TAITO CO., LTD
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • MITSUI SUGAR CO., LTD
  • Inventor
  • KIMURA, TARO
  • MIZU, MASAMI
  • SAKURAI, KAZUO
  • SHINKAI, SEIJI
  • KOUMOTO, KAZUYA
IPC(International Patent Classification)
Reference ( R and D project ) PRESTO Organization and Function AREA
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