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Fluorescent sensor for phosphate ion and phosphorylated peptide achieved

Foreign code F110003989
File No. K01205EP
Posted date Jul 7, 2011
Country EPO
Application number 03742658
Gazette No. 1484614
Gazette No. 1484614
Date of filing Jan 27, 2003
Gazette Date Dec 8, 2004
Gazette Date Nov 19, 2014
International application number JP2003000705
International publication number WO2003071280
Date of international filing Jan 27, 2003
Date of international publication Aug 28, 2003
Priority data
  • 2003JP000705 (Jan 27, 2003) WO
  • P2002-045846 (Feb 22, 2002) JP
Title Fluorescent sensor for phosphate ion and phosphorylated peptide achieved
Abstract Disclosed is a fluorescent sensor for phosphate ion and phosphorylated peptide, which comprises a phosphate anion-selective fluorescent compound expressed by the following general formula (1).
In the formula (1), FL represents a fluorescent functional group or atomic group having an aromatic ring or heterocyclic ring (for example, dimethylanthlyl group), and X represents a functional group or atomic group which will be liberated in an aqueous solution to form an anion (for example, NO3 ):
Scope of claims [claim1]
1. Use of a compound of the following formula (1) as a fluorescent sensor for phosphate ion or phosphorylated peptide: (see diagramm) wherein FL represents a fluorescent functional group or atomic group having an aromatic ring or heterocyclic ring, and X represents a functional group or atomic group which will be liberated in an aqueous solution to form an anion; and
wherein FL is selected from one of (a), (b), (c) and (d) in the following (2): (see diagramm)(see diagramm) wherein R represents hydrogen atom, an alkyl group having 1 to 4 carbon atoms or benzyl group in the formula (d); and
wherein X is NO 3, a halogen atom or ClO 4; and
wherein the compound is a phosphate anion-selective fluorescent compound.
[claim2]
2. The use according to claim 1 as a fluorescent sensor for phosphorylated peptide, wherein the compound is composed of an amino acid sequence containing a hydrophobic amino acid and an anionic amino acid in addition to a phosphorylated amino acid.
  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • Inventor
  • HAMACHI ITARU
IPC(International Patent Classification)
Reference ( R and D project ) PRESTO Organization and Function AREA
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