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ENDOKININ C/D-ORIGIN PEPTIDES

Foreign code F110004135
File No. S2009-0782-C0
Posted date Jul 12, 2011
Country WIPO
International application number 2010JP059203
International publication number WO 2010/140567
Date of international filing May 31, 2010
Date of international publication Dec 9, 2010
Priority data
  • P2009-133339 (Jun 2, 2009) JP
Title ENDOKININ C/D-ORIGIN PEPTIDES
Abstract Disclosed are peptides which can sustain an antagonistic activity to substance P over a long period of time. A peptide selected from among (a) to (c) can sustain an antagonistic activity to substance P, a pain-relieving activity and an anti-inflammatory activity over a long period of time: (a) Ala-Tyr-Gln-Leu-Glu-His-Thr-DTrp-Gln-Gly-Leu-Leu-NH2; (b) a peptide comprising a partial sequence of (a) which consists of consecutive 6 to 11 amino acids at least containing Thr-DTrp-Gln-Gly-Leu-Leu-NH2 at the C-terminal; (c) Ala-Tyr-Gln-Leu-Glu-His-Thr-Phe-Gln-DTrp-Leu-Leu-NH2; and (d) a peptide comprising a partial sequence of (c) which consists of consecutive 6 to 11 amino acids at least containing Thr-Phe-Gln-DTrp-Leu-Leu-NH2 at the C-terminal.
Scope of claims (In Japanese)
【請求項1】 以下の(a)~(e)のいずれかに示されるペプチド。
 (a) Ala-Tyr-Gln-Leu-Glu-His-Thr-DTrp-Gln-Gly-Leu-Leu-NH2(配列番号3)
[DTrpはD-型トリプトファンを示し、C末端のLeu-NH2は、カルボキシル基がアミド化されたLeuを示す]
で表されるアミノ酸配列からなるペプチド
 (b) 配列番号3のアミノ酸配列において、C末端のThr-DTrp-Gln-Gly-Leu-Leu-NH2を少なくとも含む、連続した6~11個のアミノ酸からなる部分配列からなるペプチド
 (c) Ala-Tyr-Gln-Leu-Glu-His-Thr-Phe-Gln-DTrp-Leu-Leu-NH2(配列番号4)
[DTrpはD-型トリプトファンを示し、C末端のLeu-NH2は、カルボキシル基がアミド化されたLeuを示す]
で表されるアミノ酸配列からなるペプチド
 (d) 配列番号4のアミノ酸配列における、C末端のThr-Phe-Gln-DTrp-Leu-Leu-NH2を少なくとも含む、連続した6~11個のアミノ酸からなる部分配列からなるペプチド
 (e) 上記(a)~(d)のいずれかのペプチドのアミノ酸配列において、DTrp及びC末端のLeu-NH2以外の位置で1又は数個のアミノ酸が欠失、置換又は付加されたアミノ酸配列からなり、且つサブスタンスPに対する拮抗活性、疼痛抑制活性、及び炎症抑制活性からなる群から選択される少なくとも1つの活性を有するペプチド

【請求項2】 請求項1記載のペプチドからなる、サブスタンスPに対するアンタゴニスト。

【請求項3】 請求項1記載のペプチドを有効成分として含有する疼痛治療薬。

【請求項4】 請求項1記載のペプチドを有効成分として含有する炎症治療薬。

【請求項5】 請求項1記載のペプチドを有効成分として含有する掻痒治療薬。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • UNIVERSITY OF MIYAZAKI
  • Inventor
  • NISHIMORI Toshikazu
  • NAONO Rumi
IPC(International Patent Classification)
Specified countries AE(UTILITY MODEL),AG,AL(UTILITY MODEL),AM(PROVISIONAL PATENT)(UTILITY MODEL),AO(UTILITY MODEL),AT(UTILITY MODEL),AU,AZ(UTILITY MODEL),BA,BB,BG(UTILITY MODEL),BH(UTILITY MODEL),BR(UTILITY MODEL),BW,BY(UTILITY MODEL),BZ(UTILITY MODEL),CA,CH,CL(UTILITY MODEL),CN(UTILITY MODEL),CO(UTILITY MODEL),CR(UTILITY MODEL),CU(INVENTOR'S CERTIFICATE),CZ(UTILITY MODEL),DE(UTILITY MODEL),DK(UTILITY MODEL),DM,DO(UTILITY MODEL),DZ,EC(UTILITY MODEL),EE(UTILITY MODEL),EG(UTILITY MODEL),ES(UTILITY MODEL),FI(UTILITY MODEL),GB,GD,GE(UTILITY MODEL),GH(UTILITY CERTIFICATE),GM,GT(UTILITY MODEL),HN(UTILITY MODEL),HR(CONSENSUAL PATENT),HU(UTILITY MODEL),ID,IL,IN,IS,JP(UTILITY MODEL),KE(UTILITY MODEL),KG(UTILITY MODEL),KM,KN,KP(INVENTOR'S CERTIFICATE)(UTILITY MODEL),KR(UTILITY MODEL),KZ(PROVISIONAL PATENT)(UTILITY MODEL),LA,LC,LK,LR,LS(UTILITY MODEL),LT,LU,LY,MA,MD(UTILITY MODEL),ME,MG,MK,MN,MW,MX(UTILITY MODEL),MY(UTILITY-INNOVATION),MZ(UTILITY MODEL),NA,NG,NI(UTILITY MODEL),NO,NZ,OM(UTILITY MODEL),PE(UTILITY MODEL),PG,PH(UTILITY MODEL),PL(UTILITY MODEL),PT(UTILITY MODEL),RO,RS(PETTY PATENT),RU(UTILITY MODEL),SC,SD,SE,SG,SK(UTILITY MODEL),SL(UTILITY MODEL),SM,ST,SV(UTILITY MODEL),SY,TH(PETTY PATENT),TJ(UTILITY MODEL),TM(PROVISIONAL PATENT),TN,TR(UTILITY MODEL),TT(UTILITY CERTIFICATE),TZ,UA(UTILITY MODEL),UG(UTILITY CERTIFICATE),US,UZ(UTILITY MODEL),VC(UTILITY CERTIFICATE),VN(PATENT FOR UTILITY SOLUTION),ZA,ZM,ZW,EP(AL,AT,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LT,LU,LV,MC,MK,MT,NL,NO,PL,PT,RO,SE,SI,SK,SM,TR),OA(BF(UTILITY MODEL),BJ(UTILITY MODEL),CF(UTILITY MODEL),CG(UTILITY MODEL),CI(UTILITY MODEL),CM(UTILITY MODEL),GA(UTILITY MODEL),GN(UTILITY MODEL),GQ(UTILITY MODEL),GW(UTILITY MODEL),ML(UTILITY MODEL),MR(UTILITY MODEL),NE(UTILITY MODEL),SN(UTILITY MODEL),TD(UTILITY MODEL),TG(UTILITY MODEL)),AP(BW(UTILITY MODEL),GH(UTILITY MODEL),GM(UTILITY MODEL),KE(UTILITY MODEL),LR(UTILITY MODEL),LS(UTILITY MODEL),MW(UTILITY MODEL),MZ(UTILITY MODEL),NA(UTILITY MODEL),SD(UTILITY MODEL),SL(UTILITY MODEL),SZ(UTILITY MODEL),TZ(UTILITY MODEL),UG(UTILITY MODEL),ZM(UTILITY MODEL),ZW(UTILITY MODEL)),EA(AM,AZ,BY,KG,KZ,MD,RU,TJ,TM)

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