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RAT MODEL WITH THE ONSET OF PROSTATE CANCER achieved

Foreign code F110004249
File No. A031-20CA
Posted date Jul 13, 2011
Country Canada
Application number 2400966
Gazette No. 2400966
Gazette No. 2400966
Date of filing Jun 13, 2000
Gazette Date Aug 23, 2001
Gazette Date May 19, 2009
Priority data
  • P2000-042491 (Feb 21, 2000) JP
Title RAT MODEL WITH THE ONSET OF PROSTATE CANCER achieved
Abstract

To provide a rat model with the onset of prostate cancer in which the prosta te cancer including an invasive cancer can be developed and can be bred for generation s stably. A rat model with the onset of prostate cancer which can develop prostate cancer including invasive cancer and can be bred for generations stably is established by: ligating an SV40 large T antigen gene onto the downstream of rat probasin ge ne promoter

the resulting PBSVT transgene is introduced into a fertilized egg of a Sprague-Dawley rat

after the introduction, the fertilized egg is transplant ed into a recipient rat

a transgenic rat obtained from the recipient rat is then mate d with a wild- type Sprague-Dawley rat

the transgenic offspring rats thus obtained are similarly can be bred for generations thereafter

and transgenic rats developing prostate cancer are selected through histopathological observation of the prostate.

  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY CORPORATION
  • Inventor
  • TAKAHASHI, SATORU,
  • SHIRAI, TOMOYUKI,
  • ASAMOTO, MAKOTO
IPC(International Patent Classification)
Reference ( R and D project ) CREST Host Defense Mechanism AREA
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