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RECEPTOR PROTEINS SPECIFICALLY RECOGNIZING BACTERIAL DNA achieved

Foreign code F110004252
File No. A031-29CA
Posted date Jul 13, 2011
Country Canada
Application number 2385302
Gazette No. 2385302
Gazette No. 2385302
Date of filing Jun 5, 2001
Gazette Date Jan 24, 2002
Gazette Date Aug 25, 2009
Priority data
  • P2000-219652 (Jul 19, 2000) JP
Title RECEPTOR PROTEINS SPECIFICALLY RECOGNIZING BACTERIAL DNA achieved
Abstract

The present invention provides a receptor protein specifically recognizing bacterial DNA having an unmethylated CpG sequence, a genomic DNA encoding it, an experimental animal model useful for examining responsiveness of a host immune cell against a bacterial infectious disease. DNA encoding a receptor protein specifically recognizing bacterial DNA having an unmethylated CpG sequence is screened by BLAST search, a number of EST clones having high homology with various TLRs is screened, these clones are used as a probe to isolate a full-length cDNA from mouse macrophage cDNA library, and the sequence of bases of the cDNA is analyzed to confirm that it is TLR9 comprising a conserved regions such as LRR and TIR regions, and then a knockout mouse is produced to confir m that TLR9 is a receptor protein of oligonucleotides having an unmethylated CpG sequenc e of bacterial DNA.

  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY CORPORATION
  • Inventor
  • HEMMI, HIROAKI,
  • AKIRA, SHIZUO
IPC(International Patent Classification)
Reference ( R and D project ) CREST Host Defense Mechanism AREA
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