RECEPTOR PROTEINS SPECIFICALLY RECOGNIZING BACTERIAL DNA
|Posted date||Jul 13, 2011|
|Date of filing||Jun 5, 2001|
|Gazette Date||Jan 24, 2002|
|Gazette Date||Aug 25, 2009|
|Title||RECEPTOR PROTEINS SPECIFICALLY RECOGNIZING BACTERIAL DNA|
The present invention provides a receptor protein specifically recognizing bacterial DNA having an unmethylated CpG sequence, a genomic DNA encoding it, an experimental animal model useful for examining responsiveness of a host immune cell against a bacterial infectious disease. DNA encoding a receptor protein specifically recognizing bacterial DNA having an unmethylated CpG sequence is screened by BLAST search, a number of EST clones having high homology with various TLRs is screened, these clones are used as a probe to isolate a full-length cDNA from mouse macrophage cDNA library, and the sequence of bases of the cDNA is analyzed to confirm that it is TLR9 comprising a conserved regions such as LRR and TIR regions, and then a knockout mouse is produced to confir m that TLR9 is a receptor protein of oligonucleotides having an unmethylated CpG sequenc e of bacterial DNA.
|IPC(International Patent Classification)||
|Reference ( R and D project )||CREST Host Defense Mechanism AREA|
Contact Information for " RECEPTOR PROTEINS SPECIFICALLY RECOGNIZING BACTERIAL DNA "
- Japan Science and Technology Agency Department of Intellectual Property Management
- URL: http://www.jst.go.jp/chizai/
- Address: 5-3, Yonbancho, Chiyoda-ku, Tokyo, Japan , 102-8666
- Fax: 81-3-5214-8476