NON-HUMAN ANIMAL MODEL UNRESPONSIVE TO MYCOPLASMA DERIVED LIPOPROTEIN/LIPOPEPTIDE
|Posted date||Jul 13, 2011|
|Date of filing||Jul 31, 2001|
|Gazette Date||Jan 29, 2003|
|Gazette Date||Feb 23, 2010|
|Title||NON-HUMAN ANIMAL MODEL UNRESPONSIVE TO MYCOPLASMA DERIVED LIPOPROTEIN/LIPOPEPTIDE|
An object of the present invention is to provide a non-human animal model unresponsive to a mycoplasma-derived lipoprotein/lipopeptide, and a method for screening an inhibitor or a promoter for a response to a mycoplasma-derived lipoprotein with the use of the non-human animal model. A non-human animal model whose function of a gene that encodes a protein such as TLR6 that specifically recognizes a mycoplasma-derived lipoprotein is deficient on its chromosome, for example, a TLR6 knockout mouse, is generated.
With the use of the non-human animal model unresponsive to a mycoplasma-derived lipoprotein or an immune cell such as a macrophage derived from the non-human animal model, a subject material and a mycoplasma-derived lipoprotein, a response to a mycoplasma-derived lipoprotein in the non-human animal model or the immune cell is measured/evaluated, and then an inhibitor or a promoter for a response to that is screened.
|IPC(International Patent Classification)||
|Reference ( R and D project )||CREST Host Defense Mechanism AREA|
Contact Information for " NON-HUMAN ANIMAL MODEL UNRESPONSIVE TO MYCOPLASMA DERIVED LIPOPROTEIN/LIPOPEPTIDE "
- Japan Science and Technology Agency Department of Intellectual Property Management
- URL: http://www.jst.go.jp/chizai/
- Address: 5-3, Yonbancho, Chiyoda-ku, Tokyo, Japan , 102-8666
- Fax: 81-3-5214-8476