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NON-HUMAN ANIMAL MODEL UNRESPONSIVE TO MYCOPLASMA DERIVED LIPOPROTEIN/LIPOPEPTIDE achieved

Foreign code F110004254
File No. A031-33CA
Posted date Jul 13, 2011
Country Canada
Application number 2416949
Gazette No. 2416949
Gazette No. 2416949
Date of filing Jul 31, 2001
Gazette Date Jan 29, 2003
Gazette Date Feb 23, 2010
Priority data
  • P2000-232451 (Jul 31, 2000) JP
Title NON-HUMAN ANIMAL MODEL UNRESPONSIVE TO MYCOPLASMA DERIVED LIPOPROTEIN/LIPOPEPTIDE achieved
Abstract

An object of the present invention is to provide a non-human animal model unresponsive to a mycoplasma-derived lipoprotein/lipopeptide, and a method for screening an inhibitor or a promoter for a response to a mycoplasma-derived lipoprotein with the use of the non-human animal model. A non-human animal model whose function of a gene that encodes a protein such as TLR6 that specifically recognizes a mycoplasma-derived lipoprotein is deficient on its chromosome, for example, a TLR6 knockout mouse, is generated.

With the use of the non-human animal model unresponsive to a mycoplasma-derived lipoprotein or an immune cell such as a macrophage derived from the non-human animal model, a subject material and a mycoplasma-derived lipoprotein, a response to a mycoplasma-derived lipoprotein in the non-human animal model or the immune cell is measured/evaluated, and then an inhibitor or a promoter for a response to that is screened.

  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY CORPORATION
  • Inventor
  • AKIRA, SHIZUO,
  • TAKEUCHI, OSAMU
IPC(International Patent Classification)
Reference ( R and D project ) CREST Host Defense Mechanism AREA
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