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MFG-E8-L REGULATES PHAGOCYTIC REMOVAL OF APOPTOTIC CELLS BY MACROPHAGES achieved

Foreign code F110004297
File No. A131-11CA
Posted date Jul 13, 2011
Country Canada
Application number 2467908
Gazette No. 2467908
Gazette No. 2467908
Date of filing Nov 19, 2002
Gazette Date May 30, 2003
Gazette Date Dec 31, 2013
Priority data
  • P2001-354282 (Nov 20, 2001) JP
Title MFG-E8-L REGULATES PHAGOCYTIC REMOVAL OF APOPTOTIC CELLS BY MACROPHAGES achieved
Abstract

The present invention is to provide a removal promoter for apoptotic cells which is capable of immediately removing apoptotic cells in vivo by macrophages, or a removal inhibitor which inhibits the removal of apoptotic cells in vivo by macrophages. A removal promoter for apoptotic cells in vivo containing the milk fat globule-EGF factor 8-L (MFG-E8-L), MFG-E8-L mutant having removal promotion action for apoptotic cells in vivo by macrophages, or preferably a recombinant human or mouse MFG-E8-L, or a recombinant human or mouse MFG-E8-L mutant as an active ingredient is prepared. Such removal promoters specifically bind to apoptotic cells and promote the phagocytosis of apoptotic cells by macrophages by recognizing aminophospholipids such as phosphatidylserine exposed on apoptotic cell surface. On the other hand, a point mutation (D89E) MFG-E8-L mutant is used as a removal inhibitor.

  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • Inventor
  • NAGATA, SHIGEKAZU
IPC(International Patent Classification)
Reference ( R and D project ) CREST Structure and Function of Genomes AREA
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