PROCESS FOR PRODUCING NERVE STEM CELLS, MOTOR NEURONS, AND GABAERGIC NEURONS FROM EMBRYONIC STEM CELLS
|Posted date||Jul 14, 2011|
|Date of filing||Oct 3, 2001|
|Gazette Date||Oct 17, 2002|
|Gazette Date||Jun 7, 2011|
|Title||PROCESS FOR PRODUCING NERVE STEM CELLS, MOTOR NEURONS, AND GABAERGIC NEURONS FROM EMBRYONIC STEM CELLS|
A process for producing motor neurons and GABAergic neurons characterized by comprising suspension-culturing embryonic stem cells in the presence or absence of a protein noggin to form embryoids, deriving the embryoids into nerve stem cells by suspension culture in the presence of a fibroblast growth factor and a sonic hedgehog protein, and then differentiating the same. According to this method, at least motor neurons and GABAergic neurons can be systematically and efficiently produced from ES cells. Selective acquisition of neurons would be applicable to the transplant therapy for amyotrophic lateral sclerosis, Huntington's chorea, Alzheimer's disease, etc.
|IPC(International Patent Classification)||
|Reference ( R and D project )||CREST Development, Differentiation, and Regeneration in Biological Systems AREA|
Contact Information for " PROCESS FOR PRODUCING NERVE STEM CELLS, MOTOR NEURONS, AND GABAERGIC NEURONS FROM EMBRYONIC STEM CELLS "
- Japan Science and Technology Agency Department of Intellectual Property Management
- URL: http://www.jst.go.jp/chizai/
- Address: 5-3, Yonbancho, Chiyoda-ku, Tokyo, Japan , 102-8666
- Fax: 81-3-5214-8476