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PROCESS FOR PRODUCING NERVE STEM CELLS, MOTOR NEURONS, AND GABAERGIC NEURONS FROM EMBRYONIC STEM CELLS meetings achieved

Foreign code F110004348
File No. A192-02CA
Posted date Jul 14, 2011
Country Canada
Application number 2443151
Gazette No. 2443151
Gazette No. 2443151
Date of filing Oct 3, 2001
Gazette Date Oct 17, 2002
Gazette Date Jun 7, 2011
Priority data
  • P2001-099074 (Mar 30, 2001) JP
Title PROCESS FOR PRODUCING NERVE STEM CELLS, MOTOR NEURONS, AND GABAERGIC NEURONS FROM EMBRYONIC STEM CELLS meetings achieved
Abstract

A process for producing motor neurons and GABAergic neurons characterized by comprising suspension-culturing embryonic stem cells in the presence or absence of a protein noggin to form embryoids, deriving the embryoids into nerve stem cells by suspension culture in the presence of a fibroblast growth factor and a sonic hedgehog protein, and then differentiating the same. According to this method, at least motor neurons and GABAergic neurons can be systematically and efficiently produced from ES cells. Selective acquisition of neurons would be applicable to the transplant therapy for amyotrophic lateral sclerosis, Huntington's chorea, Alzheimer's disease, etc.

  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY CORPORATION
  • Inventor
  • SHIMAZAKI, TAKUYA,
  • OKANO, HIDEYUKI
IPC(International Patent Classification)
Reference ( R and D project ) CREST Development, Differentiation, and Regeneration in Biological Systems AREA
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