Top > Search of International Patents > Numb protein expression inhibitors by musashi 1

Numb protein expression inhibitors by musashi 1 achieved

Foreign code F110004349
File No. A192-04CA
Posted date Jul 14, 2011
Country Canada
Application number 2418088
Gazette No. 2418088
Gazette No. 2418088
Date of filing Nov 22, 2001
Gazette Date Jan 31, 2003
Gazette Date Jan 14, 2014
International application number JP2001010231
International publication number WO2002099102
Date of international filing Nov 22, 2001
Date of international publication Dec 12, 2002
Priority data
  • P2001-164412 (May 31, 2001) JP
  • 2001JP010231 (Nov 22, 2001) WO
Title Numb protein expression inhibitors by musashi 1 achieved
Abstract An Numb protein expression inhibitor comprising, as active ingredient, Musashi 1 protein, a polypeptide having an amino acid sequence obtained by replacement, deletion, addition or insertion of at least one amino acid in an amino acid sequence of Musashi 1 protein, or a gene encoding said polypeptide.
By the present invention, a new function of Musashi 1 protein has been elucidated.
Described specifically, Musashi 1 protein inhibits expression of Numb protein having a neuronal differentiation regulating function and potentiates the activity of the Notch signaling system, so that Musashi 1 protein can be used as a therapeutic for various diseases of the central nervous system.
  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • Inventor
  • IMAI TAKAO
  • TOKUNAGA AKINORI
  • YOSHIDA TETSU
  • MIKOSHIBA KATSUHIKO
  • NAKAFUKU MASATO
  • OKANO HIDEYUKI
IPC(International Patent Classification)
Reference ( R and D project ) CREST Development, Differentiation, and Regeneration in Biological Systems AREA
Please contact us by E-mail or facsimile if you have any interests on this patent.

PAGE TOP

close
close
close
close
close
close