Numb protein expression inhibitors by musashi 1
|Posted date||Jul 14, 2011|
|Date of filing||Nov 22, 2001|
|Gazette Date||Jan 31, 2003|
|Gazette Date||Jan 14, 2014|
|International application number||JP2001010231|
|International publication number||WO2002099102|
|Date of international filing||Nov 22, 2001|
|Date of international publication||Dec 12, 2002|
|Title||Numb protein expression inhibitors by musashi 1|
An Numb protein expression inhibitor comprising, as active ingredient, Musashi 1 protein, a polypeptide having an amino acid sequence obtained by replacement, deletion, addition or insertion of at least one amino acid in an amino acid sequence of Musashi 1 protein, or a gene encoding said polypeptide.
By the present invention, a new function of Musashi 1 protein has been elucidated.
Described specifically, Musashi 1 protein inhibits expression of Numb protein having a neuronal differentiation regulating function and potentiates the activity of the Notch signaling system, so that Musashi 1 protein can be used as a therapeutic for various diseases of the central nervous system.
|IPC(International Patent Classification)||
|Reference ( R and D project )||CREST Development, Differentiation, and Regeneration in Biological Systems AREA|
Contact Information for " Numb protein expression inhibitors by musashi 1 "
- Japan Science and Technology Agency Department of Intellectual Property Management
- URL: http://www.jst.go.jp/chizai/
- Address: 5-3, Yonbancho, Chiyoda-ku, Tokyo, Japan , 102-8666
- Fax: 81-3-5214-8476