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Immunostimulating agents achieved

Foreign code F110004383
File No. B18-01WO
Posted date Jul 14, 2011
Country Canada
Application number 2527756
Gazette No. 2527756
Gazette No. 2527756
Date of filing May 13, 2004
Gazette Date Nov 25, 2004
Gazette Date May 6, 2014
International application number JP2004006793
International publication number WO2004100965
Date of international filing May 13, 2004
Date of international publication Nov 25, 2004
Priority data
  • P2003-136876 (May 15, 2003) JP
  • 2004JP006793 (May 13, 2004) WO
Title Immunostimulating agents achieved
Abstract Disclosed is a new type of immunostimulating agent comprising an immunostimulating oligonucleotide complexed with a carrier which is safe and has a high transfection effect.
The carrier complexed with the immunostimulating oligonucleotide to form the immunostimulating agent is a polysaccharide having .beta.-1,3-bonds (preferably .beta.-1,3-glucan such as schizophyllan).
A preferred example of the immunostimulating oligonucleotide is one containing an unmethylated CpG motif.
The polysaccharide for use is preferably modified with nucleic acid-binding functional group and/or cell membrane-affinitive functional group.
  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • MITSUI SUGAR
  • Inventor
  • MIZU MASAMI
  • SHINKAI SEIJI
  • SAKURAI KAZUO
  • KOUMOTO KAZUYA
  • NUMATA MUNENORI
  • MATSUMOTO TAKAHIRO
IPC(International Patent Classification)
Reference ( R and D project ) SORST Selected in Fiscal 2001
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